CITED4
| Gene Symbol | CITED4 |
|---|---|
| Entrez Gene | 163732 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 |
| Other Description | MRG-2|MSG1-related protein 2|cbp/p300-interacting transactivator 4|transcriptional co-activator 4 |
| Swissprots | Q96RK1 |
| Accessions | AAK64235 AAL73989 CAN89457 CAN89458 CAP11404 CAP11405 EAX07195 Q96RK1 BC035496 AAH35496 BC052559 AAH52559 NM_133467 NP_597724 |
| Function | Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}. Cytoplasm {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}. |
| Tissue Specificity | Expressed in most tissues examined with highest levels of expression in heart, liver, skeletal muscle and pancreas. Also expressed in bladder cell line ECV-304 and in various breast cancer cell lines. Also detected in both in situ and invasive breast tumors where its expression is down-regulated and mostly restricted to the cytoplasm of malignant epithelium. Down-regulation of expression is associated with elevated levels of HIF1A and increased tumor growth and angiogenesis. {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}. |
CITED4 CRISPR/Cas9 KO Plasmid (h) - sc-410354 from Santa Cruz Biotechnology
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CITED4 HDR Plasmid (h) - sc-410354-HDR from Santa Cruz Biotechnology
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CITED4 Double Nickase Plasmid (h) - sc-410354-NIC from Santa Cruz Biotechnology
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CITED4 Double Nickase Plasmid (h2) - sc-410354-NIC-2 from Santa Cruz Biotechnology
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CITED4 CRISPR Activation Plasmid (h) - sc-410354-ACT from Santa Cruz Biotechnology
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CITED4 CRISPR Activation Plasmid (h2) - sc-410354-ACT-2 from Santa Cruz Biotechnology
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CITED4 Lentiviral Activation Particles (h) - sc-410354-LAC from Santa Cruz Biotechnology
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CITED4 Lentiviral Activation Particles (h2) - sc-410354-LAC-2 from Santa Cruz Biotechnology
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CITED4 siRNA (h) - sc-60387 from Santa Cruz Biotechnology
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CITED4 shRNA Plasmid (h) - sc-60387-SH from Santa Cruz Biotechnology
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CITED4 shRNA (h) Lentiviral Particles - sc-60387-V from Santa Cruz Biotechnology
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CITED4 RNAi - H00163732-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN6146 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6146 from Sigma-Aldrich
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CITED4 siRNA (Human) - CRJ5997 from Cohesion Biosciences
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CITED4 - MBS8202543 from MyBioSource
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shRNA set against Human CITED4 (NM_133467.2) - SHH264265 from Creative biogene
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shRNA set against Human CITED4(NM_133467.2) - SHG144865 from Creative biogene
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Human CITED4 siRNA - orb276498 from Biorbyt
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CITED4 shRNA Plasmid (Human) - CHJ5997 from Cohesion Biosciences
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CITED4 miRNA 3'UTR clone - MiUTR1H-02171 from Creative biogene
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