CAMKK2

Gene Symbol CAMKK2
Entrez Gene 10645
Alt Symbol CAMKK, CAMKKB
Species Human
Gene Type protein-coding
Description calcium/calmodulin-dependent protein kinase kinase 2, beta
Other Description CAMKK beta protein|caM-KK 2|caM-KK beta|caM-kinase kinase 2|caM-kinase kinase beta|calcium/calmodulin-dependent protein kinase beta|calcium/calmodulin-dependent protein kinase kinase 2
Swissprots Q8IUG2 Q8WY05 Q96RR4 O94883 Q9UER3 Q96RP1 Q8WY03 Q9UES2 A8K7Q7 Q96RP2 Q8WY04 Q8IUG3 Q9Y5N2 Q96RR3 Q8N3I4 Q8WY06 Q9BWE9
Accessions AAK91829 AAK91830 EAW98247 EAW98248 EAW98249 EAW98250 EAW98251 EAW98252 EAW98253 EAW98254 EAW98255 EAW98256 EAW98257 EAW98258 Q96RR4 AA678930 AB018330 BAA34507 AB081336 BAC19840 AB081337 BAC19841 AF091074 AAC72943 AF101264 AAD04566 AF140507 AAD31507 AF287630 AAK64600 AF287631 AAK64601 AF321385 AAL37215 AF321386 AAL37216 AF321387 AAL37217 AF321388 AAL37218 AF425668 AAN37388 AI612762 AK024748 AK292072 BAF84761 AK300865 BAG62514 AL834322 CAD38990 BC000318 AAH00318 BC026060 AAH26060 BF972593 DA075361 DQ893410 ABM84336 DQ896785 ABM87784 XM_005253822 XP_005253879 XM_005253823 XP_005253880 XM_005253824 XP_005253881 XM_011537762 XP_011536064 XM_011537763 XP_011536065 XM_011537764 XP_011536066 XM_011537765 XP_011536067 NM_001270485 NP_001257414 NM_001270486 NP_001257415 NM_006549 NP_006540 NM_153499 NP_705719 NM_153500 NP_705720 NM_172214 NP_757363 NM_172215 NP_757364 NM_172216 NP_757365 NM_172226 NP_757380
Function Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin- binding domain are inactive. Efficiently phosphorylates 5'-AMP- activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}.
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:21957496}. Cell projection {ECO:0000269|PubMed:21957496}. Note=Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction. {ECO:0000250}.
Tissue Specificity Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung. {ECO:0000269|PubMed:9662074}.
Top Pathways Adipocytokine signaling pathway, Alcoholism, Oxytocin signaling pathway, AMPK signaling pathway

Phospho-CaMKK2 (Ser511) Antibody - 12818 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various tissues using Phospho-CaMKK2 (Ser511) Antibody (upper). The phospho-specificity of the antibody was verified by blocking with a phosphopeptide (middle) or nonphosphopeptide (lower).

CaMKKβ (H-95) - sc-50341 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CaMKKβ (H-95): sc-50341. Western blot analysis of CaMKKβ expression in rat cerebellum (A) and mouse brain (B) tissue extracts.

CaMKKβ (L-19) - sc-9629 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CaMKKβ (L-19): sc-9629. Western blot analysis of CaMKKβ expression in rat cerebellum (A) and mouse brain (B) tissue extracts.

CaMKKβ (V-18) - sc-9630 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CaMKKβ (C-18) - sc-9631 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CaMKKβ (J-22) - sc-130712 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
CaMKK (J-22): sc-130712. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human brain tissue showing cytoplasmic localization.

CaMKKβ (ZZ9) - sc-100364 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
CaMKKβ (ZZ9): sc-100364. Western blot analysis of CaMKKβ expression in IMR-32 whole cell lysate.

Anti-CAMKK2 antibody - ab168818 from Abcam

Prices $387.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CAMKK2 antibody (ab168818) at 1 µg/mlLane 1 : 293T whole cell lysateLane 2 : HeLa whole cell lysateLane 3 : Jurkat whole cell lysateLysates/proteins at 50 µg per lane.developed using the ECL technique

Anti-CAMKK2 antibody - ab96531 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of paraformaldehyde fixed HeLa using ab96531 at 1/200 dilution: (1) without DNA probe; (2) merged with DNA probe.

Anti-CAMKK2 antibody - ab135979 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CAMKK2 antibody (ab135979) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-CAMKK2 antibody - C-terminal - ab70909 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CAMKK2 antibody - C-terminal (ab70909) at 1/50 dilutionLane 1 : Nontransfected 293 cell lysateLane 2 : 293 cell lysate transiently transfected with the CAMKK2 geneLysates/proteins at 2 µg per lane.

Anti-CAMKK2 antibody - N-terminal - ab70908 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CAMKK2 antibody - N-terminal (ab70908) at 1/50 dilutionLane 1 : Nontransfected 293 cell lysateLane 2 : 293 cell lysate transiently transfected with the CAMKK2 geneLysates/proteins at 2 µg per lane.

Anti-CAMKK2 Antibody - LS-C125241 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMKK2 Antibody (aa107-156) - LS-C111489 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CAMKK2 antibody LS-C111489 Western blot of 721_B cell lysate.

Anti-CAMKK2 Antibody (aa42-71, AP) - LS-C253341 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMKK2 Antibody (aa42-71, APC) - LS-C253343 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMKK2 Antibody (aa42-71, FITC) - LS-C253345 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMKK2 Antibody (aa42-71, Azide-free, HRP) - LS-C253346 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMKK2 Antibody (N-Terminus, AP) - LS-C275831 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMKK2 Antibody (aa42-71, PE) - LS-C253347 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMKK2 Antibody (N-Terminus, APC) - LS-C275832 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMKK2 Antibody (N-Terminus, Biotin) - LS-C275833 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMKK2 Antibody (N-Terminus, FITC) - LS-C275837 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMKK2 Antibody (N-Terminus, Azide-free, HRP) - LS-C275838 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CAMKK2 Antibody (aa52-82) - LS-C98306 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human prostate carcinoma tissue reacted with CAMKK2 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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