CAMKK2
| Gene Symbol | CAMKK2 |
|---|---|
| Entrez Gene | 10645 |
| Alt Symbol | CAMKK, CAMKKB |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium/calmodulin-dependent protein kinase kinase 2, beta |
| Other Description | CAMKK beta protein|caM-KK 2|caM-KK beta|caM-kinase kinase 2|caM-kinase kinase beta|calcium/calmodulin-dependent protein kinase beta|calcium/calmodulin-dependent protein kinase kinase 2 |
| Swissprots | Q8IUG2 Q8WY05 Q96RR4 O94883 Q9UER3 Q96RP1 Q8WY03 Q9UES2 A8K7Q7 Q96RP2 Q8WY04 Q8IUG3 Q9Y5N2 Q96RR3 Q8N3I4 Q8WY06 Q9BWE9 |
| Accessions | AAK91829 AAK91830 EAW98247 EAW98248 EAW98249 EAW98250 EAW98251 EAW98252 EAW98253 EAW98254 EAW98255 EAW98256 EAW98257 EAW98258 Q96RR4 AA678930 AB018330 BAA34507 AB081336 BAC19840 AB081337 BAC19841 AF091074 AAC72943 AF101264 AAD04566 AF140507 AAD31507 AF287630 AAK64600 AF287631 AAK64601 AF321385 AAL37215 AF321386 AAL37216 AF321387 AAL37217 AF321388 AAL37218 AF425668 AAN37388 AI612762 AK024748 AK292072 BAF84761 AK300865 BAG62514 AL834322 CAD38990 BC000318 AAH00318 BC026060 AAH26060 BF972593 DA075361 DQ893410 ABM84336 DQ896785 ABM87784 XM_005253822 XP_005253879 XM_005253823 XP_005253880 XM_005253824 XP_005253881 XM_011537762 XP_011536064 XM_011537763 XP_011536065 XM_011537764 XP_011536066 XM_011537765 XP_011536067 NM_001270485 NP_001257414 NM_001270486 NP_001257415 NM_006549 NP_006540 NM_153499 NP_705719 NM_153500 NP_705720 NM_172214 NP_757363 NM_172215 NP_757364 NM_172216 NP_757365 NM_172226 NP_757380 |
| Function | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin- binding domain are inactive. Efficiently phosphorylates 5'-AMP- activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
| Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:21957496}. Cell projection {ECO:0000269|PubMed:21957496}. Note=Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction. {ECO:0000250}. |
| Tissue Specificity | Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung. {ECO:0000269|PubMed:9662074}. |
| Top Pathways | Adipocytokine signaling pathway, Alcoholism, Oxytocin signaling pathway, AMPK signaling pathway |
CaMKKβ siRNA (h) - sc-38955 from Santa Cruz Biotechnology
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CaMKKβ shRNA Plasmid (h) - sc-38955-SH from Santa Cruz Biotechnology
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CaMKKβ shRNA (h) Lentiviral Particles - sc-38955-V from Santa Cruz Biotechnology
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CaMKK2 RNAi - H00010645-R20 from Novus Biologicals
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CaMKK2 RNAi - H00010645-R19 from Novus Biologicals
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CaMKK2 RNAi - H00010645-R15 from Novus Biologicals
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CaMKK2 RNAi - H00010645-R17 from Novus Biologicals
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CaMKK2 RNAi - H00010645-R16 from Novus Biologicals
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MISSION® esiRNA - EHU083851 from Sigma-Aldrich
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MISSION® siRNA - SIHK0268 from Sigma-Aldrich
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MISSION® siRNA - SIHK0267 from Sigma-Aldrich
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MISSION® siRNA - SIHK0269 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5323 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5323 from Sigma-Aldrich
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CAMKK2 siRNA (Human) - CRH7255 from Cohesion Biosciences
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CaMKK2 RNAi - H00010645-R21 from Novus Biologicals
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CaMKK2 RNAi - H00010645-R18 from Novus Biologicals
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CAMKK2 - MBS829881 from MyBioSource
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shRNA set against Human CAMKK2 (NM_006549.3) - SHH254081 from Creative biogene
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shRNA set against Human CAMKK2(NM_153499.2) - SHG138727 from Creative biogene
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shRNA set against Human CAMKK2(NM_006549.3) - SHG138745 from Creative biogene
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shRNA set against Human CAMKK2(NM_153500.1) - SHG138763 from Creative biogene
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shRNA set against Human CAMKK2(NM_172216.1) - SHG138769 from Creative biogene
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shRNA set against Human CAMKK2(NM_153500.1) - SHG138802 from Creative biogene
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shRNA set against Human CAMKK2(NM_172216.1) - SHG138903 from Creative biogene
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