CAMKK2

Gene Symbol CAMKK2
Entrez Gene 10645
Alt Symbol CAMKK, CAMKKB
Species Human
Gene Type protein-coding
Description calcium/calmodulin-dependent protein kinase kinase 2, beta
Other Description CAMKK beta protein|caM-KK 2|caM-KK beta|caM-kinase kinase 2|caM-kinase kinase beta|calcium/calmodulin-dependent protein kinase beta|calcium/calmodulin-dependent protein kinase kinase 2
Swissprots Q8IUG2 Q8WY05 Q96RR4 O94883 Q9UER3 Q96RP1 Q8WY03 Q9UES2 A8K7Q7 Q96RP2 Q8WY04 Q8IUG3 Q9Y5N2 Q96RR3 Q8N3I4 Q8WY06 Q9BWE9
Accessions AAK91829 AAK91830 EAW98247 EAW98248 EAW98249 EAW98250 EAW98251 EAW98252 EAW98253 EAW98254 EAW98255 EAW98256 EAW98257 EAW98258 Q96RR4 AA678930 AB018330 BAA34507 AB081336 BAC19840 AB081337 BAC19841 AF091074 AAC72943 AF101264 AAD04566 AF140507 AAD31507 AF287630 AAK64600 AF287631 AAK64601 AF321385 AAL37215 AF321386 AAL37216 AF321387 AAL37217 AF321388 AAL37218 AF425668 AAN37388 AI612762 AK024748 AK292072 BAF84761 AK300865 BAG62514 AL834322 CAD38990 BC000318 AAH00318 BC026060 AAH26060 BF972593 DA075361 DQ893410 ABM84336 DQ896785 ABM87784 XM_005253822 XP_005253879 XM_005253823 XP_005253880 XM_005253824 XP_005253881 XM_011537762 XP_011536064 XM_011537763 XP_011536065 XM_011537764 XP_011536066 XM_011537765 XP_011536067 NM_001270485 NP_001257414 NM_001270486 NP_001257415 NM_006549 NP_006540 NM_153499 NP_705719 NM_153500 NP_705720 NM_172214 NP_757363 NM_172215 NP_757364 NM_172216 NP_757365 NM_172226 NP_757380
Function Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin- binding domain are inactive. Efficiently phosphorylates 5'-AMP- activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}.
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:21957496}. Cell projection {ECO:0000269|PubMed:21957496}. Note=Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction. {ECO:0000250}.
Tissue Specificity Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung. {ECO:0000269|PubMed:9662074}.
Top Pathways Adipocytokine signaling pathway, Alcoholism, Oxytocin signaling pathway, AMPK signaling pathway

Human CAMKK2 full length protein - ab161089 from Abcam

Category Protein
Prices $402.00
Sizes 10 µg
Source Wheat germ
Species Human
ab161089 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human CAMKK2 protein fragment - ab161090 from Abcam

Category Protein
Prices $402.00
Sizes 10 µg
Source Wheat germ
Species Human
ab161090 on a 12.5% SDS-PAGE stained with Coomassie Blue.

CAMKK2 Antibody Blocking Peptide - LS-E3741 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CAMKK2 Antibody Blocking Peptide - LS-E8702 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CAMKK2 Antibody Blocking Peptide - LS-E19188 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CaMKK2 Partial Recombinant Protein - H00010645-Q01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

CaMKK2 Recombinant Protein - H00010645-P01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

Recombinant Human CaMKK2 Protein - P3849 from Novus Biologicals

Category Protein
Prices $1,559.00
Sizes 5 µg
Source Insect
Species Human

CaMKK2 Peptide - P2264 from Novus Biologicals

Category Peptide
Species Human

CAMKK2-Antibody-N-term-G67-Blocking-Peptide - BP7117d from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CAMKK2-Antibody-C-term-Blocking-Peptide - BP7117b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CAMKK2 - H00010645-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

CAMKK2 - H00010645-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

CAMKK2 - H00010645-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CAMKK2 - H00010645-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CAMKK2 - P3849 from Acris Antibodies

Category Protein
Prices $1,230.00
Sizes 5 µg
Species Human

CAMKK2 fusion protein - ag2093 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human CAMKK2, GST-tagged, Active - CAMKK2-270H from Creative Biomart

Category Protein
Source Sf9 insect cells using baculovirus .

Recombinant Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) - RPL286Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

CaMKK2, active - 14-931M from EMD Millipore

Prices $2,441.00
Sizes 250 µg also available in 10μg size as catalog # 14-931 and in bulk as catalog # 14-931-k.
Source N-terminal 6His-tagged, recombinant, human CaMKK2 full length, expressed by baculovirus in Sf21 insect cells

CaMKK2, active - 14-931-K from EMD Millipore

Source N-terminal 6His-tagged, recombinant, human CaMKK2 full length, expressed by baculovirus in Sf21 insect cells
Species Human

CaMKK2, active - 14-931 from EMD Millipore

Prices $380.00
Sizes 10 µg also available in 250μg size as catalog # 14-931m and in bulk as catalog # 14-931-k.
Source N-terminal 6His-tagged, recombinant, human CaMKK2 full length, expressed by baculovirus in Sf21 insect cells

Recombinant Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) - RPL286Hu01 from Cloud-clone

Category Protein
Source E.coli
Species Human

Recombinant Human Calcium/calmodulin-dependent protein kinase kinase 2(CAMKK2) - CSB-YP822299HU CSB-EP822299HU CSB-BP822299HU CSB-MP822299HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CAMKK2 (transcript variant 7) - TP303468 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
CAMKK2
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