ARID5B

Gene Symbol	ARID5B
Entrez Gene	84159
Alt Symbol	DESRT, MRF-2, MRF2
Species	Human
Gene Type	protein-coding
Description	AT rich interactive domain 5B (MRF1-like)
Other Description	ARID domain-containing protein 5B|AT-rich interactive domain 5B (MRF1-like)|AT-rich interactive domain-containing protein 5B|MRF1-like protein|modulator recognition factor 2 (MRF2)
Swissprots	Q9H786 Q14865 Q32Q59 Q05DG6 B4DLB3 Q8N421 Q5VST4 Q6NZ42 Q7Z3M4
Accessions	EAW54226 EAW54227 EAW54228 Q14865 AI149153 AK024803 BAB15012 AK123882 AK296921 BAG59475 AL049471 BC015120 AAH15120 BC017404 BC036831 AAH36831 BC056680 BC066345 AAH66345 BC107800 AAI07801 BC152736 AAI52737 BC156570 AAI56571 BG615173 BX352258 BX472565 BX537690 CAD97814 BX641020 CAE46013 BX648835 DB014195 LN607831 CEF49518 M73837 AAA59870 XM_011540262 XP_011538564 NM_001244638 NP_001231567 NM_032199 NP_115575
Function	Transcription coactivator that binds to the 5'-AATA[CT]- 3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2- ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. {ECO:0000269|PubMed:21532585}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355}.
Tissue Specificity	Widely expressed, including in liver (at protein level). {ECO:0000269|PubMed:21532585}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Mrf-2 (L-14) - sc-163093 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-ARID5B antibody - ab118112 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ARID5B antibody - ab155409 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ARID5B antibody - N-terminal - ab179733 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ARID5B Antibody (aa389-418, APC) - LS-C208042 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ARID5B Antibody (aa389-418, Biotin) - LS-C208043 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ARID5B Antibody (aa389-418, FITC) - LS-C208044 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ARID5B Antibody (aa389-418, AP) - LS-C208041 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ARID5B Antibody (aa389-418, PE) - LS-C208047 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ARID5B Antibody (aa389-418, Azide-free, HRP) - LS-C208045 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ARID5B Antibody (aa1031-1080) - LS-C135246 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ARID5B Antibody (aa875-925) - LS-C288987 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ARID5B Antibody (aa1138-1188) - LS-C288988 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ARID5B Antibody (aa388-418) - LS-C319591 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ARID5B Antibody (aa77-126) - LS-C201585 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ARID5B Antibody (aa389-418) - LS-C159115 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ARID5B Antibody (aa500-550) IHC-plus™ - LS-B7987 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

ARID5B Antibody - NBP2-24657 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

ARID5B Antibody - NBP1-83622 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ARID5B Antibody - NBP1-69169 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

ARID5B Antibody (1C2) - H00084159-M04 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C2

Anti-ARID5B antibody produced in rabbit - HPA015037 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-ARID5B, (C-terminal) antibody produced in mouse - SAB1405305 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C2

ARID5B Antibody - N-terminal region (ARP50704_P050) - ARP50704_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ARID5B antibody - C-terminal region (ARP50705_P050) - ARP50705_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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