Gene Symbol | BHLHE22 |
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Entrez Gene | 27319 |
Alt Symbol | BHLHB5, Beta3, CAGL85, TNRC20 |
Species | Human |
Gene Type | protein-coding |
Description | basic helix-loop-helix family, member e22 |
Other Description | basic helix-loop-helix domain containing, class B, 5|class B basic helix-loop-helix protein 5|class E basic helix-loop-helix protein 22|trinucleotide repeat containing 20|trinucleotide repeat-containing gene 20 protein |
Swissprots | Q8NFJ8 |
Accessions | AAM28881 EAW86876 Q8NFJ8 AA927689 AI867692 AI968349 AK091333 AK293979 BAG57349 AW206610 BC033056 BC045748 BC156671 AAI56672 BK000273 DAA01053 NM_152414 NP_689627 |
Function | Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Brain-specific, with the highest expression in the cerebellum. {ECO:0000269|PubMed:12213201}. |
BETA 3 CRISPR/Cas9 KO Plasmid (h) - sc-402142 from Santa Cruz Biotechnology
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BETA 3 HDR Plasmid (h) - sc-402142-HDR from Santa Cruz Biotechnology
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BETA 3 Double Nickase Plasmid (h) - sc-402142-NIC from Santa Cruz Biotechnology
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BETA 3 Double Nickase Plasmid (h2) - sc-402142-NIC-2 from Santa Cruz Biotechnology
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BETA 3 CRISPR Activation Plasmid (h) - sc-402142-ACT from Santa Cruz Biotechnology
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BETA 3 CRISPR Activation Plasmid (h2) - sc-402142-ACT-2 from Santa Cruz Biotechnology
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BETA 3 Lentiviral Activation Particles (h) - sc-402142-LAC from Santa Cruz Biotechnology
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BETA 3 Lentiviral Activation Particles (h2) - sc-402142-LAC-2 from Santa Cruz Biotechnology
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BETA 3 siRNA (h) - sc-42066 from Santa Cruz Biotechnology
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BETA 3 shRNA Plasmid (h) - sc-42066-SH from Santa Cruz Biotechnology
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BETA 3 shRNA (h) Lentiviral Particles - sc-42066-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN3967 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3967 from Sigma-Aldrich
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BHLHE22 siRNA (Human) - CRH9076 from Cohesion Biosciences
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BHLHE22 - MBS8200255 from MyBioSource
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shRNA set against Human BHLHE22 (NM_152414.4) - SHH246582 from Creative biogene
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Human BHLHE22 siRNA - orb269578 from Biorbyt
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BHLHE22 shRNA Plasmid (Human) - CHH9076 from Cohesion Biosciences
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BHLHE22 miRNA 3'UTR clone - MiUTR3H-12922 from Creative biogene
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