| Gene Symbol |
CAPN1
|
| Entrez Gene |
823
|
| Alt Symbol |
CANP, CANP1, CANPL1, muCANP, muCL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calpain 1, (mu/I) large subunit
|
| Other Description |
CANP 1|calcium-activated neutral proteinase 1|calpain mu-type|calpain, large polypeptide L1|calpain-1 catalytic subunit|calpain-1 large subunit|cell proliferation-inducing gene 30 protein|cell proliferation-inducing protein 30|micromolar-calpain
|
| Swissprots |
Q2TTR0 Q6DHV4 P07384
|
| Accessions |
AAV41878 EAW74366 EAW74367 EAW74368 EAW74369 EAW74370 EAW74371 P07384 AK022319 AK025380 AK097277 AK301538 BAG63037 AK311001 AK315556 BAG37932 AY550975 AAT52221 BC008751 AAH08751 BC015091 BC017200 AAH17200 BC075862 AAH75862 BE018156 DA788342 DC365116 DC372552 DQ892905 ABM83831 DQ896600 ABM87599 X04366 CAA27881 XM_006718698 XP_006718761 XM_011545292 XP_011543594 NM_001198868 NP_001185797 NM_001198869 NP_001185798 NM_005186 NP_005177 NR_040008
|
| Function |
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:8769305}. Cell membrane {ECO:0000269|PubMed:8769305}. Note=Translocates to the plasma membrane upon Ca(2+) binding.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Apoptosis, Alzheimer's disease, Protein processing in endoplasmic reticulum
|
![Western Blot: Calpain 1 Overexpression Lysate (Adult Normal) [NBL1-08677] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Calpain 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11090_Calpain%25201%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-08677-img0002.jpg)