CAPN1

Gene Symbol CAPN1
Entrez Gene 823
Alt Symbol CANP, CANP1, CANPL1, muCANP, muCL
Species Human
Gene Type protein-coding
Description calpain 1, (mu/I) large subunit
Other Description CANP 1|calcium-activated neutral proteinase 1|calpain mu-type|calpain, large polypeptide L1|calpain-1 catalytic subunit|calpain-1 large subunit|cell proliferation-inducing gene 30 protein|cell proliferation-inducing protein 30|micromolar-calpain
Swissprots Q2TTR0 Q6DHV4 P07384
Accessions AAV41878 EAW74366 EAW74367 EAW74368 EAW74369 EAW74370 EAW74371 P07384 AK022319 AK025380 AK097277 AK301538 BAG63037 AK311001 AK315556 BAG37932 AY550975 AAT52221 BC008751 AAH08751 BC015091 BC017200 AAH17200 BC075862 AAH75862 BE018156 DA788342 DC365116 DC372552 DQ892905 ABM83831 DQ896600 ABM87599 X04366 CAA27881 XM_006718698 XP_006718761 XM_011545292 XP_011543594 NM_001198868 NP_001185797 NM_001198869 NP_001185798 NM_005186 NP_005177 NR_040008
Function Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:8769305}. Cell membrane {ECO:0000269|PubMed:8769305}. Note=Translocates to the plasma membrane upon Ca(2+) binding.
Tissue Specificity Ubiquitous.
Top Pathways Apoptosis, Alzheimer's disease, Protein processing in endoplasmic reticulum

Calpain 1 CRISPR/Cas9 KO Plasmid (h) - sc-400929 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Calpain 1 HDR Plasmid (h) - sc-400929-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Calpain 1 Double Nickase Plasmid (h) - sc-400929-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Calpain 1 Double Nickase Plasmid (h2) - sc-400929-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Calpain 1 CRISPR Activation Plasmid (h) - sc-400929-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Calpain 1 CRISPR Activation Plasmid (h2) - sc-400929-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Calpain 1 Lentiviral Activation Particles (h) - sc-400929-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Calpain 1 Lentiviral Activation Particles (h2) - sc-400929-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Calpain 1 siRNA (h) - sc-29885 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Calpain 1 shRNA Plasmid (h) - sc-29885-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Calpain 1 shRNA (h) Lentiviral Particles - sc-29885-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Calpain 1 RNAi - H00000823-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU032581 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg
<B>Immunoblotting</B><BR/>CAPN1: <B>Cat. No. EHU032581</B>: Western blot analysis of Calpain 1 in HeLa cells.<BR/><B>Lanes</B><BR/>1. HeLa cells transfected with Renilla Luciferase esiRNA (RLUC, <B>Cat. No. EHURLUC</B>) as negative control.<BR/>2. HeLa cells transfected with CAPN1 esiRNA (<B>Cat. No. EHU032581</B>). Quantitative-Immunoblotting: Lysates were separated on SDS-Page and probed with mouse Monoclonal Anti-μ-Calpain (1:1000) Clone: 2H2A7C2 (<B>Cat. No. C267</B>) and goat Anti-GAPDH (1:7000) (Acris) antibodies. The signal intensities of indicated bands were quantified using an Odyssey infrared imaging system (LiCOR) and normalized to the GAPDH signal. At 72h post transfection, a 76% CAPN1 protein reduction was measured between the negative control RLUC and the sample treated with CAPN1 esiRNA.

CompoZr® Knockout ZFN Kit - CKOZFN1471 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1471 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05737 from Sigma-Aldrich

Category miRNA

CAPN1 siRNA (Human) - CRH0577 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CAPN1 - MBS8224636 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CAPN1 (NM_005186.3) - SHH254269 from Creative biogene

Category siRNA
Species Reactivities Human

CAPN1 shRNA Plasmid (Human) - CHH0577 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CAPN1 miRNA 3'UTR clone - MiUTR3H-00328 from Creative biogene

Species Reactivities Human
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