| Gene Symbol |
FBXO32
|
| Entrez Gene |
114907
|
| Alt Symbol |
Fbx32, MAFbx
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box protein 32
|
| Other Description |
F-box only protein 32|atrogin 1|atrogin-1|muscle atrophy F-box protein
|
| Swissprots |
Q969P5 A4KYM0
|
| Accessions |
EAW92040 EAW92041 EAW92042 EAW92043 Q969P5 AI077844 AJ420108 CAD12251 AK023391 AK056986 BAB71333 AK096904 AK124390 AK125888 AY059629 AAL16407 BC022416 BC024030 AAH24030 BC100020 AAI00021 BC120963 AAI20964 BC120964 AAI20965 DB503484 EF143260 ABO37797 HQ447898 ADQ32382 NM_001242463 NP_001229392 NM_058229 NP_478136 NM_148177 NP_680482
|
| Function |
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. {ECO:0000269|PubMed:15531760}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:22249105}. Nucleus {ECO:0000269|PubMed:22249105}. Note=Shuttles between Cytoplasm and the nucleus.
|
| Tissue Specificity |
Specifically expressed in cardiac and skeletal muscle.
|