| Gene Symbol |
RXFP1
|
| Entrez Gene |
59350
|
| Alt Symbol |
LGR7, RXFPR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
relaxin/insulin-like family peptide receptor 1
|
| Other Description |
leucine-rich repeat-containing G protein-coupled receptor 7|relaxin receptor 1
|
| Swissprots |
Q3KU25 Q9HBX9 Q2M215 Q3KU26 B4DTV2 B4DHD1 Q3KU24
|
| Accessions |
AAY41039 EAX04856 EAX04857 Q9HBX9 AB208943 BAD92180 AF190500 AAG17167 AI653269 AK122647 BAG53639 AK294694 BAG57853 AK295040 BAG58092 AK300379 BAG62114 AK307889 AK312470 AY899848 AAX85196 AY899849 AAX85197 AY899850 AAX85198 BC112142 AAI12143 BC113617 AAI13618 BC143556 BC143557 BC143558 BC143559 BX647975 BX647980 BX647985 CR748189 DA156504 DA241507 DA308373 DA519897 DC334052 HQ258496 ADR83250 XM_011532174 XP_011530476 XM_011532175 XP_011530477 XM_011532176 XP_011530478 XM_011532177 XP_011530479 XM_011532178 XP_011530480 XM_011532179 XP_011530481 NM_001253727 NP_001240656 NM_001253728 NP_001240657 NM_001253729 NP_001240658 NM_001253730 NP_001240659 NM_001253732 NP_001240661 NM_001253733 NP_001240662 NM_021634 NP_067647 NR_045579 NR_045580 NR_045581 NR_045582 NR_045583 NR_045584
|
| Function |
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:16051677}; Multi-pass membrane protein {ECO:0000269|PubMed:16051677}.
|
| Tissue Specificity |
Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen. {ECO:0000269|PubMed:16051677}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|