| Gene Symbol |
DCLRE1A
|
| Entrez Gene |
9937
|
| Alt Symbol |
PSO2, SNM1, SNM1A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DNA cross-link repair 1A
|
| Other Description |
DNA cross-link repair 1A protein|DNA-crosslink repair gene SNM1|SNM1 homolog A
|
| Swissprots |
Q6PJP8 Q6P5Y3 Q14701 D3DRC1 Q6PKL4
|
| Accessions |
AAT09762 ABI49507 EAW49489 EAW49490 Q6PJP8 AK307187 BC013124 AAH13124 BC062582 AAH62582 D42045 BAA07646 DA456679 DB224073 H98725 XM_006718090 XP_006718153 XM_011540429 XP_011538731 NM_001271816 NP_001258745 NM_014881 NP_055696
|
| Function |
May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. {ECO:0000269|PubMed:15542852}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10848582, ECO:0000269|PubMed:12446782, ECO:0000269|PubMed:15572677}. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross- linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1.
|
| Tissue Specificity |
Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:12446782}.
|