Gene Symbol | DCLRE1A |
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Entrez Gene | 9937 |
Alt Symbol | PSO2, SNM1, SNM1A |
Species | Human |
Gene Type | protein-coding |
Description | DNA cross-link repair 1A |
Other Description | DNA cross-link repair 1A protein|DNA-crosslink repair gene SNM1|SNM1 homolog A |
Swissprots | Q6PJP8 Q6P5Y3 Q14701 D3DRC1 Q6PKL4 |
Accessions | AAT09762 ABI49507 EAW49489 EAW49490 Q6PJP8 AK307187 BC013124 AAH13124 BC062582 AAH62582 D42045 BAA07646 DA456679 DB224073 H98725 XM_006718090 XP_006718153 XM_011540429 XP_011538731 NM_001271816 NP_001258745 NM_014881 NP_055696 |
Function | May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. {ECO:0000269|PubMed:15542852}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:10848582, ECO:0000269|PubMed:12446782, ECO:0000269|PubMed:15572677}. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross- linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1. |
Tissue Specificity | Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:12446782}. |
DCLRE1A / SNM1 Antibody Blocking Peptide - LS-E25717 from LifeSpan Bioscience
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DCLRE1A / SNM1 Antibody Blocking Peptide - LS-E26003 from LifeSpan Bioscience
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DCLRE1A-Antibody-Center-Blocking-Peptide - BP9871c from Abgent, a WuXi AppTec company
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SNM1 (C Term) blocking peptide - GTX14805-PEP from GeneTex
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SNM1/DCLRE1A (internal) blocking peptide - GTX89462-PEP from GeneTex
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SNM1 Peptide - AC21-0546-P from Abcore
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SNM1 Peptide - AC21-0831-P from Abcore
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DCLRE1A Peptide - 45-466P from ProSci
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SNM1 Peptide - 46-394P from ProSci
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DCLRE1A fusion protein - Ag5425 from Proteintech Group
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DCLRE1A fusion protein - ag5799 from Proteintech Group
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Recombinant Human DCLRE1A, GST-tagged - DCLRE1A-11855H from Creative Biomart
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Recombinant Human DNA cross-link repair 1A protein(DCLRE1A) ,partial - CSB-YP761360HU CSB-EP761360HU CSB-BP761360HU CSB-MP761360HU from Cusabio
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SNM1, Peptide - MBS428096 from MyBioSource
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SNM1/DCLRE1A, Peptide - MBS425831 from MyBioSource
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SNM1 Recombinant Protein Antigen - NBP1-89663PEP from Novus Biologicals
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DCLRE1A Peptide, Human - M34GP04087H from Creative Peptides
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DNA cross-link repair 1A protein (DCLRE1A), partial, Recombinant Protein - MBS1452721 from MyBioSource
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