Gene Symbol | OLFM4 |
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Entrez Gene | 10562 |
Alt Symbol | GC1, GW112, OLM4, OlfD, UNQ362, bA209J19.1, hGC-1, hOLfD |
Species | Human |
Gene Type | protein-coding |
Description | olfactomedin 4 |
Other Description | G-CSF-stimulated clone 1 protein|antiapoptotic protein GW112|olfactomedin-4 |
Swissprots | Q86T22 Q5VWG0 O95362 Q6UX06 |
Accessions | EAW52052 EAW52053 Q6UX06 AF097021 AAC72970 AI560739 AK000683 AK300947 BAG62576 AY358567 AAQ88930 BC047740 AAH47740 BC117329 AAI17330 DA928098 HQ258281 ADR83035 NM_006418 NP_006409 |
Function | May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. {ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:17270022, ECO:0000269|PubMed:20724538}. |
Subcellular Location | Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901). {ECO:0000269|PubMed:15059901, ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:20724538}. |
Tissue Specificity | Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues. {ECO:0000269|PubMed:11867215, ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:17270022, ECO:0000269|PubMed:20724538}. |
Human OLFM4 full length protein - ab112393 from Abcam
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Human OLFM4 full length protein - ab167764 from Abcam
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Human OLFM4 peptide - ab98247 from Abcam
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OLFM4 / Olfactomedin 4 Antibody Blocking Peptide - LS-E29417 from LifeSpan Bioscience
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OLFM4 / Olfactomedin 4 Antibody Blocking Peptide - LS-E29416 from LifeSpan Bioscience
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OLFM4 / Olfactomedin 4 Antibody Blocking Peptide - LS-E29817 from LifeSpan Bioscience
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Recombinant Human OLFM4 Protein - H00010562-P01 from Novus Biologicals
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OLFM4 Blocking Peptide - 33R-2362 from Fitzgerald
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Human Olfactomedin 4 Protein - abx068378 from Abbexa
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Olfactomedin-4 - H00010562-P01-10 from Acris Antibodies
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Olfactomedin-4 - H00010562-P01-25 from Acris Antibodies
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Olfactomedin 4 (OLFM4), Human - 20-6380 from ARP American Research Products
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Olfactomedin 4 Recombinant Protein - 96-566 from ProSci
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Recombinant Human OLFM4, His tagged - OLFM4-3222H from Creative Biomart
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OLFM4 - PN201673 from Elabscience
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Human Olfactomedin-4 Recombinant - RKQ6UX06 from Reprokine
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Recombinant Olfactomedin 4 (OLFM4) - RPA162Hu01 from Uscn Life Science Inc.
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Recombinant Olfactomedin 4 (OLFM4) - RPA162Mu01 from Uscn Life Science Inc.
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Recombinant Olfactomedin 4 (OLFM4) - RPA162Mu02 from Uscn Life Science Inc.
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Recombinant Olfactomedin 4 (OLFM4) - RPA162Bo01 from Uscn Life Science Inc.
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Human OLFM4 / GW112 Protein (His Tag) - 11639-H08H-10 from Sino Biological
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Human Olfactomedin-4 / OLFM4 Protein - OL4-H5221 from ACROBiosystems
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Recombinant Olfactomedin 4 (OLFM4) - RPA162Hu01 from Cloud-clone
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Recombinant Human Olfactomedin-4(OLFM4) - CSB-YP764941HU CSB-EP764941HU CSB-BP764941HU CSB-MP764941HU from Cusabio
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Olfactomedin 4 (OLFM4) - RPU143134 from Biomatik
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