| Gene Symbol | OLFM4 |
|---|---|
| Entrez Gene | 10562 |
| Alt Symbol | GC1, GW112, OLM4, OlfD, UNQ362, bA209J19.1, hGC-1, hOLfD |
| Species | Human |
| Gene Type | protein-coding |
| Description | olfactomedin 4 |
| Other Description | G-CSF-stimulated clone 1 protein|antiapoptotic protein GW112|olfactomedin-4 |
| Swissprots | Q86T22 Q5VWG0 O95362 Q6UX06 |
| Accessions | EAW52052 EAW52053 Q6UX06 AF097021 AAC72970 AI560739 AK000683 AK300947 BAG62576 AY358567 AAQ88930 BC047740 AAH47740 BC117329 AAI17330 DA928098 HQ258281 ADR83035 NM_006418 NP_006409 |
| Function | May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. {ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:17270022, ECO:0000269|PubMed:20724538}. |
| Subcellular Location | Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901). {ECO:0000269|PubMed:15059901, ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:20724538}. |
| Tissue Specificity | Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues. {ECO:0000269|PubMed:11867215, ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:17270022, ECO:0000269|PubMed:20724538}. |
GC-1 CRISPR/Cas9 KO Plasmid (h) - sc-403599 from Santa Cruz Biotechnology
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GC-1 HDR Plasmid (h) - sc-403599-HDR from Santa Cruz Biotechnology
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GC-1 Double Nickase Plasmid (h) - sc-403599-NIC from Santa Cruz Biotechnology
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GC-1 Double Nickase Plasmid (h2) - sc-403599-NIC-2 from Santa Cruz Biotechnology
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GC-1 CRISPR Activation Plasmid (h) - sc-403599-ACT from Santa Cruz Biotechnology
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GC-1 CRISPR Activation Plasmid (h2) - sc-403599-ACT-2 from Santa Cruz Biotechnology
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GC-1 Lentiviral Activation Particles (h) - sc-403599-LAC from Santa Cruz Biotechnology
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GC-1 Lentiviral Activation Particles (h2) - sc-403599-LAC-2 from Santa Cruz Biotechnology
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GC-1 siRNA (h) - sc-75113 from Santa Cruz Biotechnology
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GC-1 shRNA Plasmid (h) - sc-75113-SH from Santa Cruz Biotechnology
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GC-1 shRNA (h) Lentiviral Particles - sc-75113-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU017761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15717 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15717 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12608 from Sigma-Aldrich
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OLFM4 siRNA (Human) - CRH7183 from Cohesion Biosciences
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shRNA set against Human OLFM4 (NM_006418.4) - SHH357652 from Creative biogene
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Human OLFM4 siRNA - orb267685 from Biorbyt
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OLFM4 shRNA Plasmid (Human) - CHH7183 from Cohesion Biosciences
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OLFM4 miRNA 3'UTR clone - MiUTR3H-13121 from Creative biogene
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