Gene Symbol | STAM2 |
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Entrez Gene | 10254 |
Alt Symbol | Hbp, STAM2A, STAM2B |
Species | Human |
Gene Type | protein-coding |
Description | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 |
Other Description | HSE1 homolog|Hrs-binding protein|STAM-2|STAM-like protein containing SH3 and ITAM domains 2|signal transducing adapter molecule 2 |
Swissprots | D3DPA1 A8K8A0 Q7LDQ0 Q9UF58 O75886 |
Accessions | AAY14712 EAX11490 EAX11491 EAX11492 O75886 AF042273 AAC63963 AF042274 AAC63964 AK023490 AK292265 BAF84954 AK292847 BAF85536 AK310863 AL133600 CAB63735 AM393419 CAL38297 BC022277 BC028740 AAH28740 BI548350 BQ000599 BU619301 DQ892427 ABM83353 DQ895641 ABM86567 XR_922831 NM_005843 NP_005834 |
Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000269|PubMed:12551915}; Peripheral membrane protein {ECO:0000269|PubMed:12551915}; Cytoplasmic side {ECO:0000269|PubMed:12551915}. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:10899310}. |
Top Pathways | Jak-STAT signaling pathway, Endocytosis |
STAM2 Antibody - 14674 from Cell Signaling Technology
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STAM2 (F-11) - sc-365600 from Santa Cruz Biotechnology
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STAM2 (H-175) - sc-98681 from Santa Cruz Biotechnology
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STAM2 (D-16) - sc-82750 from Santa Cruz Biotechnology
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Anti-STAM antibody - ab76061 from Abcam
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Anti-STAM antibody - ab81006 from Abcam
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Anti-STAM antibody [G1G5] - ab180822 from Abcam
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Anti-STAM2 (phospho Y192) antibody - ab63569 from Abcam
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Anti-STAM2 antibody - ab63372 from Abcam
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Anti-STAM2 antibody - ab56672 from Abcam
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Anti-STAM2 antibody - ab168729 from Abcam
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Anti-STAM2 antibody - ab172541 from Abcam
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Anti-STAM2 antibody [EPR8688] - ab151545 from Abcam
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Anti-STAM2 Antibody (aa142-172, APC) - LS-C241310 from LifeSpan Bioscience
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Anti-STAM2 Antibody - LS-C155414 from LifeSpan Bioscience
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Anti-STAM2 Antibody (aa142-172, AP) - LS-C241311 from LifeSpan Bioscience
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Anti-STAM2 Antibody (aa142-172, FITC) - LS-C241312 from LifeSpan Bioscience
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Anti-STAM2 Antibody (aa142-172, Biotin) - LS-C241313 from LifeSpan Bioscience
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Anti-STAM2 Antibody (aa142-172, PE) - LS-C241314 from LifeSpan Bioscience
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Anti-STAM2 Antibody (Internal) - LS-C55532 from LifeSpan Bioscience
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Anti-STAM2 Antibody (aa142-172, Azide-free, HRP) - LS-C248263 from LifeSpan Bioscience
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Anti-STAM2 Antibody (phospho-Tyr192) - LS-C313637 from LifeSpan Bioscience
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Anti-STAM2 Antibody (aa142-172) - LS-C325424 from LifeSpan Bioscience
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Anti-STAM2 Antibody (aa416-526, Azide-free) - LS-C328762 from LifeSpan Bioscience
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Anti-STAM2 Antibody (aa142-172) - LS-C161538 from LifeSpan Bioscience
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