STAM2

Gene Symbol STAM2
Entrez Gene 10254
Alt Symbol Hbp, STAM2A, STAM2B
Species Human
Gene Type protein-coding
Description signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Other Description HSE1 homolog|Hrs-binding protein|STAM-2|STAM-like protein containing SH3 and ITAM domains 2|signal transducing adapter molecule 2
Swissprots D3DPA1 A8K8A0 Q7LDQ0 Q9UF58 O75886
Accessions AAY14712 EAX11490 EAX11491 EAX11492 O75886 AF042273 AAC63963 AF042274 AAC63964 AK023490 AK292265 BAF84954 AK292847 BAF85536 AK310863 AL133600 CAB63735 AM393419 CAL38297 BC022277 BC028740 AAH28740 BI548350 BQ000599 BU619301 DQ892427 ABM83353 DQ895641 ABM86567 XR_922831 NM_005843 NP_005834
Function Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000269|PubMed:12551915}; Peripheral membrane protein {ECO:0000269|PubMed:12551915}; Cytoplasmic side {ECO:0000269|PubMed:12551915}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:10899310}.
Top Pathways Jak-STAT signaling pathway, Endocytosis

STAM2 Antibody - 14674 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using STAM2 Antibody.

STAM2 (F-11) - sc-365600 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
STAM2 (F-11): sc-365600. Western blot analysis of STAM2 expression in Caki-1 (A) and SK-N-MC (B) whole cell lysates.

STAM2 (H-175) - sc-98681 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
STAM2 (H-175): sc-98681. Western blot analysis of STAM2 expression in Caki-1 (A), HeLa (B), SK-N-MC (C) and Hep G2 (D) whole cell lysates.

STAM2 (D-16) - sc-82750 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-STAM antibody - ab76061 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-STAM antibody (ab76061) at 1/100 dilutionLane 1 : Rat brain lysatesLane 2 : Rat brain lysates treated with ab76061 pre-absorbed with Immunogenic peptide

Anti-STAM antibody - ab81006 from Abcam

Host Sheep
Clonality Polyclonal

Anti-STAM antibody [G1G5] - ab180822 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone G1G5
Anti-STAM antibody [G1G5] (ab180822) at 1/1000 dilution + HeLa cell lysate

Anti-STAM2 (phospho Y192) antibody - ab63569 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of STAM2 (phospho Y192) staining in human lung formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab63569, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-STAM2 antibody - ab63372 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-STAM2 antibody (ab63372) at 1/500 dilutionLane 1 : NIH/3T3 cell extracts treated with EGF (200ng/ml, 30mins)Lane 2 : NIH/3T3 cell extracts treated with EGF (200ng/ml, 30mins) with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-STAM2 antibody - ab56672 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-STAM2 antibody - ab168729 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-STAM2 antibody (ab168729) at 1/500 dilutionLane 1 : STAM2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugated secondary antibody at 1/2500 dilution

Anti-STAM2 antibody - ab172541 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-STAM2 antibody (ab172541) at 1 µg/mlLane 1 : STAM2 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryPeroxidase conjugated Goat Anti-Rabbit IgG (H+L) at 1/7500 dilution

Anti-STAM2 antibody [EPR8688] - ab151545 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8688
Overlay histogram showing HeLa cells stained with ab151545 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab151545, 1/10000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HeLa cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-STAM2 Antibody (aa142-172, APC) - LS-C241310 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STAM2 Antibody - LS-C155414 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: Jurkat 7.5% SDS PAGE STAM2 antibody diluted at 1:1000

Anti-STAM2 Antibody (aa142-172, AP) - LS-C241311 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STAM2 Antibody (aa142-172, FITC) - LS-C241312 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STAM2 Antibody (aa142-172, Biotin) - LS-C241313 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STAM2 Antibody (aa142-172, PE) - LS-C241314 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STAM2 Antibody (Internal) - LS-C55532 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (1 ug/ml) staining of Human Spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-STAM2 Antibody (aa142-172, Azide-free, HRP) - LS-C248263 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STAM2 Antibody (phospho-Tyr192) - LS-C313637 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-STAM2 Antibody (aa142-172) - LS-C325424 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STAM2 Antibody (aa416-526, Azide-free) - LS-C328762 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-STAM2 Antibody (aa142-172) - LS-C161538 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
STAM2 Antibody western blot of ZR-75-1 cell line lysates (35 ug/lane). The STAM2 antibody detected the STAM2 protein (arrow).
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