STAM2
| Gene Symbol | STAM2 |
|---|---|
| Entrez Gene | 10254 |
| Alt Symbol | Hbp, STAM2A, STAM2B |
| Species | Human |
| Gene Type | protein-coding |
| Description | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 |
| Other Description | HSE1 homolog|Hrs-binding protein|STAM-2|STAM-like protein containing SH3 and ITAM domains 2|signal transducing adapter molecule 2 |
| Swissprots | D3DPA1 A8K8A0 Q7LDQ0 Q9UF58 O75886 |
| Accessions | AAY14712 EAX11490 EAX11491 EAX11492 O75886 AF042273 AAC63963 AF042274 AAC63964 AK023490 AK292265 BAF84954 AK292847 BAF85536 AK310863 AL133600 CAB63735 AM393419 CAL38297 BC022277 BC028740 AAH28740 BI548350 BQ000599 BU619301 DQ892427 ABM83353 DQ895641 ABM86567 XR_922831 NM_005843 NP_005834 |
| Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000269|PubMed:12551915}; Peripheral membrane protein {ECO:0000269|PubMed:12551915}; Cytoplasmic side {ECO:0000269|PubMed:12551915}. |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:10899310}. |
| Top Pathways | Jak-STAT signaling pathway, Endocytosis |
Human STAM2 full length protein - ab132279 from Abcam
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Human STAM2 peptide - ab48061 from Abcam
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Human STAM2 protein fragment - ab160904 from Abcam
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STAM2 Antibody Blocking Peptide - LS-E2917 from LifeSpan Bioscience
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STAM2 Antibody Blocking Peptide - LS-E26079 from LifeSpan Bioscience
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Recombinant Human STAM2 Protein - H00010254-P01 from Novus Biologicals
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Recombinant Human STAM2 Protein - H00010254-Q01 from Novus Biologicals
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STAM2-Antibody-Center-Blocking-peptide - BP14042c from Abgent, a WuXi AppTec company
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STAM2 blocking peptide - GTX89357-PEP from GeneTex
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STAM2 Immunizing peptide - orb16885 from Biorbyt
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STAM2 (phospho-Tyr192) Blocking Peptide - abx063533 from Abbexa
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STAM2 Peptide - AC21-0907-P from Abcore
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STAM2 - H00010254-P01-02 from Acris Antibodies
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STAM2 - H00010254-Q01-10 from Acris Antibodies
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STAM2 - H00010254-Q01-25 from Acris Antibodies
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STAM2 Peptide - 46-438P from ProSci
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STAM2 fusion protein - Ag3698 from Proteintech Group
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Recombinant Human STAM2, GST-tagged - STAM2-2989H from Creative Biomart
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STAM2 (pY192) Blocking Peptide - CBP2339 from Cohesion Biosciences
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STAM2 (T188) Peptide - BS1807P from Bioworld Technology
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p-STAM2 (Y192) Peptide - BS4876P from Bioworld Technology
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Recombinant Human Signal transducing adapter molecule 2(STAM2) - CSB-YP022793HU CSB-EP022793HU CSB-BP022793HU CSB-MP022793HU from Cusabio
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Recombinant Signal Transducing Adaptor Molecule 2 (STAM2) - RPC873Hu01 from Uscn Life Science Inc.
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Recombinant Signal Transducing Adaptor Molecule 2 (STAM2) - RPC873Mu01 from Uscn Life Science Inc.
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STAM2 - TP306279 from Acris Antibodies
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