| Gene Symbol |
STAM2
|
| Entrez Gene |
10254
|
| Alt Symbol |
Hbp, STAM2A, STAM2B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
|
| Other Description |
HSE1 homolog|Hrs-binding protein|STAM-2|STAM-like protein containing SH3 and ITAM domains 2|signal transducing adapter molecule 2
|
| Swissprots |
D3DPA1 A8K8A0 Q7LDQ0 Q9UF58 O75886
|
| Accessions |
AAY14712 EAX11490 EAX11491 EAX11492 O75886 AF042273 AAC63963 AF042274 AAC63964 AK023490 AK292265 BAF84954 AK292847 BAF85536 AK310863 AL133600 CAB63735 AM393419 CAL38297 BC022277 BC028740 AAH28740 BI548350 BQ000599 BU619301 DQ892427 ABM83353 DQ895641 ABM86567 XR_922831 NM_005843 NP_005834
|
| Function |
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000269|PubMed:12551915}; Peripheral membrane protein {ECO:0000269|PubMed:12551915}; Cytoplasmic side {ECO:0000269|PubMed:12551915}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:10899310}.
|
| Top Pathways |
Jak-STAT signaling pathway, Endocytosis
|