Gene Symbol | RBMX |
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Entrez Gene | 27316 |
Alt Symbol | HNRNPG, HNRPG, RBMXP1, RBMXRT, RNMX, hnRNP-G |
Species | Human |
Gene Type | protein-coding |
Description | RNA binding motif protein, X-linked |
Other Description | RNA binding motif protein, X chromosome|RNA-binding motif protein, X chromosome|glycoprotein p43|heterogeneous nuclear ribonucleoprotein G|hnRNP G |
Swissprots | D3DWH0 P38159 E9PG86 Q969R3 Q8N8Y7 Q5JQ67 B4E3U4 |
Accessions | AAK58567 EAW88453 EAW88454 EAW88455 EAW88456 EAW88457 P38159 AA160187 AK091520 BAG52377 AK096015 BAC04674 AK097941 AK304573 BAG65364 AK304868 BAG65606 AK309911 AY464692 AAR28036 BC006550 AAH06550 BC007435 AAH07435 BM147410 BM993214 BU587845 BX647131 DA925805 DC337568 DQ893211 ABM84137 DQ896540 ABM87539 Z23064 CAA80599 NM_001164803 NP_001158275 NM_002139 NP_002130 NR_028476 NR_028477 |
Function | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single- stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. Note=Component of ribonucleosomes. Localizes in numerous small granules in the nucleus. |
Tissue Specificity | Expressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell carcinomas (at protein level). {ECO:0000269|PubMed:16707624}. |
Top Pathways | Spliceosome |
RBMX/hnRNP G (D7C2V) Rabbit mAb - 14794 from Cell Signaling Technology
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RBMX (C-17) - sc-14583 from Santa Cruz Biotechnology
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RBMX (G-17) - sc-14581 from Santa Cruz Biotechnology
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RBMX (H-80) - sc-48796 from Santa Cruz Biotechnology
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Anti-hnRNP G antibody - ab70064 from Abcam
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Anti-hnRNP G antibody - ab118688 from Abcam
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Anti-hnRNP G antibody [EPR16038] - ab190352 from Abcam
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Anti-hnRNP G antibody - C-terminal - ab177347 from Abcam
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Anti-RBMX Antibody (aa314-363) - LS-C145669 from LifeSpan Bioscience
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Anti-RBMX Antibody (aa210-259) - LS-C170358 from LifeSpan Bioscience
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Anti-RBMX Antibody (Met40) - LS-C176907 from LifeSpan Bioscience
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Anti-RBMX Antibody (aa6-55) - LS-C118881 from LifeSpan Bioscience
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hnRNP G Antibody - NBP2-34152 from Novus Biologicals
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hnRNP G Antibody - NBP1-79904 from Novus Biologicals
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Anti-HNRNP G, N-Terminal antibody produced in rabbit - SAB4501209 from Sigma-Aldrich
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Anti-RBMX antibody produced in rabbit - SAB2107655 from Sigma-Aldrich
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RBMX antibody - C-terminal region (ARP61802_P050) - ARP61802_P050 from Aviva Systems Biology
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RBMX Antibody - C-terminal region (ARP61803_P050) - ARP61803_P050 from Aviva Systems Biology
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RBMX Antibody (OAAF02254) - OAAF02254 from Aviva Systems Biology
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HNRPG antibody - orb100325 from Biorbyt
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hnRNP G Antibody - abx013479 from Abbexa
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RBMX / HNRPG antibody - AP20416PU-N from Acris Antibodies
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Anti-hnRNP G (M40) - 31-B2274 from ARP American Research Products
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Anti-hnRNP G antibody - STJ93565 from St John's Laboratory Ltd
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RBMX antibody - 11205-1-AP from Proteintech Group
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