| Gene Symbol |
ELL3
|
| Entrez Gene |
80237
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
elongation factor RNA polymerase II-like 3
|
| Other Description |
RNA polymerase II elongation factor ELL3
|
| Swissprots |
Q6I9Z7 B3KQ66 B3KX08 Q9HB65 Q9H634
|
| Accessions |
CAI93397 EAW77237 EAW77238 Q9HB65 AF276512 AAG13463 AI955716 AK026290 BAB15432 AK057528 BAG51928 AK126384 BAG54320 BC006548 AAH06548 BC019293 AAH19293 BC052599 BC062349 CR457358 CAG33639 HQ447725 ADQ32210 NM_025165 NP_079441
|
| Function |
Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex requi
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10882741}.
|
| Tissue Specificity |
Testis specific. {ECO:0000269|PubMed:10882741}.
|
