ELL3
| Gene Symbol | ELL3 |
|---|---|
| Entrez Gene | 80237 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | elongation factor RNA polymerase II-like 3 |
| Other Description | RNA polymerase II elongation factor ELL3 |
| Swissprots | Q6I9Z7 B3KQ66 B3KX08 Q9HB65 Q9H634 |
| Accessions | CAI93397 EAW77237 EAW77238 Q9HB65 AF276512 AAG13463 AI955716 AK026290 BAB15432 AK057528 BAG51928 AK126384 BAG54320 BC006548 AAH06548 BC019293 AAH19293 BC052599 BC062349 CR457358 CAG33639 HQ447725 ADQ32210 NM_025165 NP_079441 |
| Function | Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex requi |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:10882741}. |
| Tissue Specificity | Testis specific. {ECO:0000269|PubMed:10882741}. |
ELL3 CRISPR/Cas9 KO Plasmid (h) - sc-405835 from Santa Cruz Biotechnology
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ELL3 HDR Plasmid (h) - sc-405835-HDR from Santa Cruz Biotechnology
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ELL3 Double Nickase Plasmid (h) - sc-405835-NIC from Santa Cruz Biotechnology
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ELL3 Double Nickase Plasmid (h2) - sc-405835-NIC-2 from Santa Cruz Biotechnology
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ELL3 CRISPR Activation Plasmid (h) - sc-405835-ACT from Santa Cruz Biotechnology
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ELL3 CRISPR Activation Plasmid (h2) - sc-405835-ACT-2 from Santa Cruz Biotechnology
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ELL3 Lentiviral Activation Particles (h) - sc-405835-LAC from Santa Cruz Biotechnology
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ELL3 Lentiviral Activation Particles (h2) - sc-405835-LAC-2 from Santa Cruz Biotechnology
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ELL3 siRNA (h) - sc-90096 from Santa Cruz Biotechnology
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ELL3 shRNA Plasmid (h) - sc-90096-SH from Santa Cruz Biotechnology
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ELL3 shRNA (h) Lentiviral Particles - sc-90096-V from Santa Cruz Biotechnology
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ELL3 RNAi - H00080237-R01 from Novus Biologicals
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MISSION® esiRNA - EHU054801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7811 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04119 from Sigma-Aldrich
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ELL3 siRNA (Human) - CRJ2822 from Cohesion Biosciences
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ELL3 - MBS8212796 from MyBioSource
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ELL3 CRISPR/Cas9 KO Plasmid (h2) - sc-405835-KO-2 from Santa Cruz Biotechnology
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ELL3 HDR Plasmid (h2) - sc-405835-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human ELL3 (NM_025165.2) - SHH285137 from Creative biogene
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shRNA set against Human ELL3(NM_025165.2) - SHG209863 from Creative biogene
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ELL3 shRNA Plasmid (Human) - CHJ2822 from Cohesion Biosciences
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ELL3 miRNA 3'UTR clone - MiUTR1H-03197 from Creative biogene
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