ELL3

Gene Symbol	ELL3
Entrez Gene	80237
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	elongation factor RNA polymerase II-like 3
Other Description	RNA polymerase II elongation factor ELL3
Swissprots	Q6I9Z7 B3KQ66 B3KX08 Q9HB65 Q9H634
Accessions	CAI93397 EAW77237 EAW77238 Q9HB65 AF276512 AAG13463 AI955716 AK026290 BAB15432 AK057528 BAG51928 AK126384 BAG54320 BC006548 AAH06548 BC019293 AAH19293 BC052599 BC062349 CR457358 CAG33639 HQ447725 ADQ32210 NM_025165 NP_079441
Function	Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex requi
Subcellular Location	Nucleus {ECO:0000269|PubMed:10882741}.
Tissue Specificity	Testis specific. {ECO:0000269|PubMed:10882741}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ELL3 full length protein - ab164234 from Abcam Category Protein Source Wheat germ Species Human

ELL3 Antibody Blocking Peptide - LS-E5732 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELL3 Antibody Blocking Peptide - LS-E22861 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ELL3 Protein - H00080237-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ELL3-Antibody-C-term-Blocking-Peptide - BP18266b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ELL3 - H00080237-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ELL3 - H00080237-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ELL3 fusion protein - Ag2074 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human ELL3, GST-tagged - ELL3-12408H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human RNA polymerase II elongation factor ELL3(ELL3) - CSB-YP864017HU CSB-EP864017HU CSB-BP864017HU CSB-MP864017HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ELL3 Recombinant Protein Antigen - NBP1-82116PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ELL3 Peptide, Human - M34GP04865H from Creative Peptides Category Peptide Source Synthetic. Species Human

RNA polymerase II elongation factor ELL3 (ELL3), Recombinant Protein - MBS1458088 from MyBioSource Category Protein Prices $1,170.00, $1,170.00, $1,400.00, $1,400.00, $1,875.00, $1,875.00, $2,340.00, $2,340.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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