SLC12A4

Gene Symbol	SLC12A4
Entrez Gene	6560
Alt Symbol	KCC1
Species	Human
Gene Type	protein-coding
Description	solute carrier family 12 (potassium/chloride transporter), member 4
Other Description	CTC-479C5.17|electroneutral potassium-chloride cotransporter 1|erythroid K-Cl cotransporter 1|hKCC1|potassium/chloride cotransporter 1|solute carrier family 12 (potassium/chloride transporters), member 4|solute carrier family 12 member 4
Swissprots	O75893 F5H0S9 F5H066 O60632 Q13953 Q9UP95 F5H3C0 B4DZ82 Q96LD5 B4DR04 B4DF69 B7ZAV0
Accessions	AAO83657 EAW83191 EAW83192 EAW83193 EAW83194 EAW83195 EAW83196 Q9UP95 AF047338 AAC32815 AF053402 AAC35282 AF054505 AAC39684 AF054506 AAC39685 AI368074 AK026911 AK097808 BAG53532 AK293906 BAG57291 AK293956 BAG57330 AK299042 BAG61116 AK302790 BAG63994 AK310027 AK311073 AK316415 BAH14786 AY026038 AAK01946 BC021193 AAH21193 BC035480 CF272417 DC321966 DC333904 DC402650 DQ892254 ABM83180 DQ895457 ABM86383 U55054 AAC50563 NM_001145961 NP_001139433 NM_001145962 NP_001139434 NM_001145963 NP_001139435 NM_001145964 NP_001139436 NM_005072 NP_005063
Function	Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity. {ECO:0000250}.
Subcellular Location	Membrane; Multi-pass membrane protein.
Tissue Specificity	Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SLC12A4 / KCC1 Antibody Blocking Peptide - LS-E16139 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SLC12A4 / KCC1 Antibody Blocking Peptide - LS-E26489 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SLC12A4-Antibody-C-term-Blocking-Peptide - BP18058b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KCC1/SLC12A4 blocking peptide - GTX88934-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

SLC12A4 Blocking Peptide - 33R-6285 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SLC12A4 Peptide - AC21-1326-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

KCC1 Peptide - 45-792P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

SLC12A4 fusion protein - Ag8972 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SLC12A4 fusion protein - Ag8762 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human SLC12A4, His-tagged - SLC12A4-2698H from Creative Biomart Category Protein Source E.coli Species Human

KCC1/SLC12A4, Peptide - MBS425132 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

KCC1/SLC12A4 Recombinant Protein Antigen - NBP1-83067PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SLC12A4 Peptide, Human - M34GP14317H from Creative Peptides Category Peptide Source Synthetic. Species Human

Solute carrier family 12 member 4 (SLC12A4), Recombinant Protein - MBS7102289 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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