SLC12A4

Gene Symbol SLC12A4
Entrez Gene 6560
Alt Symbol KCC1
Species Human
Gene Type protein-coding
Description solute carrier family 12 (potassium/chloride transporter), member 4
Other Description CTC-479C5.17|electroneutral potassium-chloride cotransporter 1|erythroid K-Cl cotransporter 1|hKCC1|potassium/chloride cotransporter 1|solute carrier family 12 (potassium/chloride transporters), member 4|solute carrier family 12 member 4
Swissprots O75893 F5H0S9 F5H066 O60632 Q13953 Q9UP95 F5H3C0 B4DZ82 Q96LD5 B4DR04 B4DF69 B7ZAV0
Accessions AAO83657 EAW83191 EAW83192 EAW83193 EAW83194 EAW83195 EAW83196 Q9UP95 AF047338 AAC32815 AF053402 AAC35282 AF054505 AAC39684 AF054506 AAC39685 AI368074 AK026911 AK097808 BAG53532 AK293906 BAG57291 AK293956 BAG57330 AK299042 BAG61116 AK302790 BAG63994 AK310027 AK311073 AK316415 BAH14786 AY026038 AAK01946 BC021193 AAH21193 BC035480 CF272417 DC321966 DC333904 DC402650 DQ892254 ABM83180 DQ895457 ABM86383 U55054 AAC50563 NM_001145961 NP_001139433 NM_001145962 NP_001139434 NM_001145963 NP_001139435 NM_001145964 NP_001139436 NM_005072 NP_005063
Function Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity. {ECO:0000250}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.

KCC1 (H-69) - sc-366076 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

KCC1 (P-20) - sc-25037 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

KCC1 (E-14) - sc-19417 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

KCC1 (FT-94) - sc-134370 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
KCC1 (FT-94): sc-134370. Western blot analysis of KCC1 expression in human KCC1 transfected (A) and non-transfected (B) 293T whole cell lysates.

KCC1/2/3/4 (C-14) - sc-19421 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SLC12A4 antibody - ab115607 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab115607, at 5µg/ml, staining SLC12A4 in Formalin-fixed, Paraffin-embedded Human Placenta tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-SLC12A4 antibody - ab77340 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-SLC12A4 antibody (ab77340) at 0.3 µg/ml + Human Heart lysate (in RIPA buffer) at 35 µg

Anti-SLC12A4 antibody - ab58163 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab58163 SLC12A4 antibody at 1ug/ml.

Anti-SLC12A4 antibody - ab99053 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SLC12A4 antibody (ab99053) at 1 µg/ml + PANC1 cell lysate at 10 µg

Anti-SLC12A4 / KCC1 Antibody (N-Terminus) - LS-C110835 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SLC12A4 antibody LS-C110835 Western blot of PANC1 cell lysate.

Anti-SLC12A4 / KCC1 Antibody (clone 1H6) - LS-C198216 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1H6
Western Blot analysis of SLC12A4 expression in transfected 293T cell line by SLC12A4 monoclonal antibody (M01), clone 1H6.Lane 1: SLC12A4 transfected lysate(120.6 KDa).Lane 2: Non-transfected lysate.

Anti-SLC12A4 / KCC1 Antibody (aa997-1007) IHC-plus™ - LS-B2377 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-SLC12A4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2377 concentration 5 ug/ml.

Anti-SLC12A4 / KCC1 Antibody - LS-C333065 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

KCC1/SLC12A4 Antibody - NBP1-58293 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

KCC1/SLC12A4 Antibody - NBP1-83067 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KCC1/SLC12A4 Antibody - NBP1-06043 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: KCC1/SLC12A4 Antibody [NBP1-06043] - (0.3ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

KCC1/SLC12A4 Antibody (1H6) - H00006560-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1H6

Anti-KCC1/SLC12A4 antibody produced in goat - SAB2500553 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-KCC1 / SLC12A4: <B>Cat. No. SAB2500553</B>: (0.3 μg/mL) staining of Human Heart lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SLC12A4 antibody produced in rabbit - HPA041138 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SLC12A4: <B>Cat. No. HPA041138</B>: Immunohistochemical staining of human pancreas shows moderate cytoplasmic positivity in exocrine glandular cells.

Monoclonal Anti-SLC12A4 antibody produced in mouse - WH0006560M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1H6
<B>Immunoblotting</B><BR/>Monoclonal Anti-SLC12A4, <B>Cat. No. WH0006560M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~35.1 kDa using immunogen protein lysate.

Anti-SLC12A4, (N-terminal) antibody produced in rabbit - SAB2105538 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SLC12A4 (N-Terminal): <B>Cat. No. SAB2105538</B>: SLC12A4 in PANC1 cell lysates with SLC12A4 antibody at 1.0 μg/mL.

SLC12A4 antibody - N-terminal region (ARP43895_P050) - ARP43895_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KCC1--SLC12A4-Antibody - AF1582a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF1582a (0.3 µg/ml) staining of Human Heart lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

KCC1 / SLC12A4 antibody, Internal - GTX88934 from GeneTex

Prices $319.00
Sizes 100 μg
Host Goat
Clonality Polyclonal
Anti-KCC1 / SLC12A4 antibody, Internal used in Western blot. GTX88934

Goat Anti-KCC1 / SLC12A4 Antibody (OAEB01912) - OAEB01912 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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