SLC12A4

Gene Symbol SLC12A4
Entrez Gene 6560
Alt Symbol KCC1
Species Human
Gene Type protein-coding
Description solute carrier family 12 (potassium/chloride transporter), member 4
Other Description CTC-479C5.17|electroneutral potassium-chloride cotransporter 1|erythroid K-Cl cotransporter 1|hKCC1|potassium/chloride cotransporter 1|solute carrier family 12 (potassium/chloride transporters), member 4|solute carrier family 12 member 4
Swissprots O75893 F5H0S9 F5H066 O60632 Q13953 Q9UP95 F5H3C0 B4DZ82 Q96LD5 B4DR04 B4DF69 B7ZAV0
Accessions AAO83657 EAW83191 EAW83192 EAW83193 EAW83194 EAW83195 EAW83196 Q9UP95 AF047338 AAC32815 AF053402 AAC35282 AF054505 AAC39684 AF054506 AAC39685 AI368074 AK026911 AK097808 BAG53532 AK293906 BAG57291 AK293956 BAG57330 AK299042 BAG61116 AK302790 BAG63994 AK310027 AK311073 AK316415 BAH14786 AY026038 AAK01946 BC021193 AAH21193 BC035480 CF272417 DC321966 DC333904 DC402650 DQ892254 ABM83180 DQ895457 ABM86383 U55054 AAC50563 NM_001145961 NP_001139433 NM_001145962 NP_001139434 NM_001145963 NP_001139435 NM_001145964 NP_001139436 NM_005072 NP_005063
Function Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity. {ECO:0000250}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.

KCC1 CRISPR/Cas9 KO Plasmid (h) - sc-405294 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCC1 HDR Plasmid (h) - sc-405294-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCC1 Double Nickase Plasmid (h) - sc-405294-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCC1 Double Nickase Plasmid (h2) - sc-405294-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCC1 CRISPR Activation Plasmid (h) - sc-405294-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCC1 CRISPR Activation Plasmid (h2) - sc-405294-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCC1 Lentiviral Activation Particles (h) - sc-405294-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCC1 Lentiviral Activation Particles (h2) - sc-405294-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCC1 siRNA (h) - sc-42604 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCC1 shRNA Plasmid (h) - sc-42604-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCC1 shRNA (h) Lentiviral Particles - sc-42604-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCC1/SLC12A4 RNAi - H00006560-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU071291 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19406 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19406 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12230 from Sigma-Aldrich

Category miRNA

SLC12A4 siRNA (Human) - CRH4450 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC12A4 - MBS8226426 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SLC12A4 (NM_005072.4) - SHH408336 from Creative biogene

Category siRNA
Species Reactivities Human

KCC1 CRISPR/Cas9 KO Plasmid (h2) - sc-405294-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCC1 HDR Plasmid (h2) - sc-405294-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Human SLC12A4 siRNA - orb264952 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC12A4 shRNA Plasmid (Human) - CHH4450 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLC12A4 miRNA 3'UTR clone - MiUTR3H-06567 from Creative biogene

Species Reactivities Human

SLC12A4 miRNA 3'UTR clone - MiUTR3H-06568 from Creative biogene

Species Reactivities Human
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