| Gene Symbol |
CLEC11A
|
| Entrez Gene |
6320
|
| Alt Symbol |
CLECSF3, LSLCL, P47, SCGF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
C-type lectin domain family 11, member A
|
| Other Description |
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 3|C-type lectin domain family 11 member A|C-type lectin superfamily member 3|lymphocyte secreted C-type lectin|lymphocyte secreted long form of C-type lectin|stem cell growth factor|stem cell growth factor; lymphocyte secreted C-type lectin
|
| Swissprots |
B2RAD4 Q9Y240
|
| Accessions |
AAD26533 CAS01773 EAW71895 EAW71896 EAW71897 Q9Y240 AB009244 BAA32404 AF020044 AAC39569 AK314141 BAG36831 AY870345 AAX62798 BC005810 AAH05810 BQ014793 BT019673 AAV38479 BU615665 D86586 BAA21499 HQ448166 ADQ32647 NM_002975 NP_002966
|
| Function |
Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation. {ECO:0000269|PubMed:11920266}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11803813}. Secreted {ECO:0000269|PubMed:11803813}.
|
| Tissue Specificity |
Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver. {ECO:0000269|PubMed:11803813, ECO:0000269|PubMed:11920266, ECO:0000269|PubMed:9442024, ECO:0000269|PubMed:9705843}.
|