Gene Symbol | CLEC11A |
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Entrez Gene | 6320 |
Alt Symbol | CLECSF3, LSLCL, P47, SCGF |
Species | Human |
Gene Type | protein-coding |
Description | C-type lectin domain family 11, member A |
Other Description | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 3|C-type lectin domain family 11 member A|C-type lectin superfamily member 3|lymphocyte secreted C-type lectin|lymphocyte secreted long form of C-type lectin|stem cell growth factor|stem cell growth factor; lymphocyte secreted C-type lectin |
Swissprots | B2RAD4 Q9Y240 |
Accessions | AAD26533 CAS01773 EAW71895 EAW71896 EAW71897 Q9Y240 AB009244 BAA32404 AF020044 AAC39569 AK314141 BAG36831 AY870345 AAX62798 BC005810 AAH05810 BQ014793 BT019673 AAV38479 BU615665 D86586 BAA21499 HQ448166 ADQ32647 NM_002975 NP_002966 |
Function | Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation. {ECO:0000269|PubMed:11920266}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11803813}. Secreted {ECO:0000269|PubMed:11803813}. |
Tissue Specificity | Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver. {ECO:0000269|PubMed:11803813, ECO:0000269|PubMed:11920266, ECO:0000269|PubMed:9442024, ECO:0000269|PubMed:9705843}. |
SCGF CRISPR/Cas9 KO Plasmid (h) - sc-411000 from Santa Cruz Biotechnology
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SCGF HDR Plasmid (h) - sc-411000-HDR from Santa Cruz Biotechnology
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SCGF Double Nickase Plasmid (h) - sc-411000-NIC from Santa Cruz Biotechnology
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SCGF Double Nickase Plasmid (h2) - sc-411000-NIC-2 from Santa Cruz Biotechnology
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SCGF CRISPR Activation Plasmid (h) - sc-411000-ACT from Santa Cruz Biotechnology
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SCGF CRISPR Activation Plasmid (h2) - sc-411000-ACT-2 from Santa Cruz Biotechnology
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SCGF Lentiviral Activation Particles (h) - sc-411000-LAC from Santa Cruz Biotechnology
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SCGF Lentiviral Activation Particles (h2) - sc-411000-LAC-2 from Santa Cruz Biotechnology
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SCGF siRNA (h) - sc-106870 from Santa Cruz Biotechnology
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SCGF shRNA Plasmid (h) - sc-106870-SH from Santa Cruz Biotechnology
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SCGF shRNA (h) Lentiviral Particles - sc-106870-V from Santa Cruz Biotechnology
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SCGF beta RNAi - H00006320-R01 from Novus Biologicals
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MISSION® esiRNA - EHU022201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6197 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6197 from Sigma-Aldrich
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CLEC11A siRNA (Human) - CRH4258 from Cohesion Biosciences
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CLEC11A - MBS829567 from MyBioSource
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shRNA set against Human CLEC11A (NM_002975.2) - SHH264905 from Creative biogene
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shRNA set against Human CLEC11A(NM_002975.2) - SHG181243 from Creative biogene
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Human CLEC11A siRNA - orb264760 from Biorbyt
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CLEC11A shRNA Plasmid (Human) - CHH4258 from Cohesion Biosciences
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CLEC11A miRNA 3'UTR clone - MiUTR1H-02200 from Creative biogene
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