| Gene Symbol | ACLY |
|---|---|
| Entrez Gene | 47 |
| Alt Symbol | ACL, ATPCL, CLATP |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP citrate lyase |
| Other Description | ATP citrate synthase|ATP-citrate (pro-S-)-lyase|ATP-citrate synthase|citrate cleavage enzyme |
| Swissprots | Q9BRL0 B4DIM0 B4E3P0 P53396 Q13037 |
| Accessions | EAW60777 EAW60778 EAW60779 EAW60780 EAW60781 P53396 AB210035 BAE06117 AK095084 BAC04484 AK295675 BAG58532 AK304802 BAG65552 AK312315 BC006195 AAH06195 BG037168 DB072009 DQ575356 JF432308 ADZ15525 U18197 AAB60340 X64330 CAA45614 XM_005257395 XP_005257452 NM_001096 NP_001087 NM_001303274 NP_001290203 NM_001303275 NP_001290204 NM_198830 NP_942127 |
| Function | ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. {ECO:0000269|PubMed:23932781}. |
| Subcellular Location | Cytoplasm. |
| Top Pathways | Citrate cycle (TCA cycle) |