Gene Symbol | ACLY |
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Entrez Gene | 47 |
Alt Symbol | ACL, ATPCL, CLATP |
Species | Human |
Gene Type | protein-coding |
Description | ATP citrate lyase |
Other Description | ATP citrate synthase|ATP-citrate (pro-S-)-lyase|ATP-citrate synthase|citrate cleavage enzyme |
Swissprots | Q9BRL0 B4DIM0 B4E3P0 P53396 Q13037 |
Accessions | EAW60777 EAW60778 EAW60779 EAW60780 EAW60781 P53396 AB210035 BAE06117 AK095084 BAC04484 AK295675 BAG58532 AK304802 BAG65552 AK312315 BC006195 AAH06195 BG037168 DB072009 DQ575356 JF432308 ADZ15525 U18197 AAB60340 X64330 CAA45614 XM_005257395 XP_005257452 NM_001096 NP_001087 NM_001303274 NP_001290203 NM_001303275 NP_001290204 NM_198830 NP_942127 |
Function | ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. {ECO:0000269|PubMed:23932781}. |
Subcellular Location | Cytoplasm. |
Top Pathways | Citrate cycle (TCA cycle) |
ATP-citrate synthase CRISPR/Cas9 KO Plasmid (h) - sc-403146 from Santa Cruz Biotechnology
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ATP-citrate synthase HDR Plasmid (h) - sc-403146-HDR from Santa Cruz Biotechnology
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ATP-citrate synthase Double Nickase Plasmid (h) - sc-403146-NIC from Santa Cruz Biotechnology
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ATP-citrate synthase Double Nickase Plasmid (h2) - sc-403146-NIC-2 from Santa Cruz Biotechnology
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ATP-citrate synthase CRISPR Activation Plasmid (h) - sc-403146-ACT from Santa Cruz Biotechnology
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ATP-citrate synthase CRISPR Activation Plasmid (h2) - sc-403146-ACT-2 from Santa Cruz Biotechnology
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ATP-citrate synthase Lentiviral Activation Particles (h) - sc-403146-LAC from Santa Cruz Biotechnology
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ATP-citrate synthase Lentiviral Activation Particles (h2) - sc-403146-LAC-2 from Santa Cruz Biotechnology
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ATP-citrate synthase siRNA (h) - sc-45206 from Santa Cruz Biotechnology
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ATP-citrate synthase shRNA Plasmid (h) - sc-45206-SH from Santa Cruz Biotechnology
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ATP-citrate synthase shRNA (h) Lentiviral Particles - sc-45206-V from Santa Cruz Biotechnology
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ATP Citrate Lyase RNAi - H00000047-R01 from Novus Biologicals
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ATP Citrate Lyase RNAi - H00000047-R02 from Novus Biologicals
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MISSION® esiRNA - EHU081921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2719 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2719 from Sigma-Aldrich
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ACLY siRNA (Human) - CRH0035 from Cohesion Biosciences
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ACLY - MBS827995 from MyBioSource
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shRNA set against Human ACLY (NM_001096.2) - SHH230290 from Creative biogene
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shRNA set against Human ACLY(NM_001096.2) - SHG029647 from Creative biogene
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shRNA set against Human ACLY(NM_198830.1) - SHG029665 from Creative biogene
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ACLY shRNA Plasmid (Human) - CHH0035 from Cohesion Biosciences
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ACLY miRNA 3'UTR clone - MiUTR1H-00102 from Creative biogene
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ACLY miRNA 3'UTR clone - MiUTR1H-00103 from Creative biogene
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