Gene Symbol | DGAT1 |
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Entrez Gene | 8694 |
Alt Symbol | ARAT, ARGP1, DGAT, DIAR7 |
Species | Human |
Gene Type | protein-coding |
Description | diacylglycerol O-acyltransferase 1 |
Other Description | ACAT related gene product 1|acyl coenzyme A:cholesterol acyltransferase related gene 1|acyl-CoA retinol O-fatty-acyltransferase|acyl-CoA:diacylglycerol acyltransferase|diglyceride acyltransferase |
Swissprots | B2RWQ2 Q96BB8 O75907 D3DWL6 |
Accessions | EAW82127 EAW82128 EAW82129 EAW82130 O75907 AB057815 BAC66170 AF059202 AAC63997 BC006263 AAH06263 BC015762 AAH15762 BC023565 AAH23565 BC106084 AAI06085 BC150649 AAI50650 BI907285 CK300256 DQ892286 ABM83212 DQ895486 ABM86412 HY016503 XM_011517356 XP_011515658 NM_012079 NP_036211 |
Function | Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. {ECO:0000269|PubMed:16214399, ECO:0000269|PubMed:9756920}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Top Pathways | Fat digestion and absorption, Glycerolipid metabolism, Retinol metabolism |
DGAT1 (A-5) - sc-271934 from Santa Cruz Biotechnology
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DGAT1 (H-255) - sc-32861 from Santa Cruz Biotechnology
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DGAT1 (G-6) - sc-271935 from Santa Cruz Biotechnology
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DGAT1 (N-20) - sc-26170 from Santa Cruz Biotechnology
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Anti-DGAT1 antibody [EPR13430-4] - N-terminal - ab181180 from Abcam
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Anti-DGAT1 Antibody (Internal, Biotin) - LS-C141387 from LifeSpan Bioscience
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Anti-DGAT1 Antibody (Internal, DY650) - LS-C141388 from LifeSpan Bioscience
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Anti-DGAT1 Antibody (Internal, DY488) - LS-C141389 from LifeSpan Bioscience
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Anti-DGAT1 Antibody (Internal, DY550) - LS-C141391 from LifeSpan Bioscience
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Anti-DGAT1 Antibody (Internal, HRP) - LS-C141390 from LifeSpan Bioscience
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Anti-DGAT1 Antibody (aa200-300) - LS-C49135 from LifeSpan Bioscience
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Anti-DGAT1 Antibody (aa308) - LS-C190193 from LifeSpan Bioscience
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Anti-DGAT1 Antibody (aa180-427, FITC) - LS-C301911 from LifeSpan Bioscience
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Anti-DGAT1 Antibody (aa180-427, Biotin) - LS-C297837 from LifeSpan Bioscience
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Anti-DGAT1 Antibody - LS-C146985 from LifeSpan Bioscience
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Anti-DGAT1 Antibody (aa78-127) - LS-C186729 from LifeSpan Bioscience
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Anti-DGAT1 Antibody (aa180-427) - LS-C294118 from LifeSpan Bioscience
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Anti-DGAT1 Antibody - LS-C334965 from LifeSpan Bioscience
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Anti-DGAT1 Antibody (aa217-229) IHC-plus⢠- LS-B5914 from LifeSpan Bioscience
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Anti-DGAT1 Antibody (aa67-79) IHC-plus⢠- LS-B9542 from LifeSpan Bioscience
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DGAT1 Antibody - NB110-41487 from Novus Biologicals
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DGAT1 Antibody - NB100-57086 from Novus Biologicals
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DGAT1 Antibody - NBP2-26215 from Novus Biologicals
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DGAT1 Antibody [FITC] - NB110-41487F from Novus Biologicals
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DGAT1 Antibody [DyLight 405] - NB110-41487V from Novus Biologicals
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