SLC5A8

Gene Symbol SLC5A8
Entrez Gene 160728
Alt Symbol AIT, SMCT, SMCT1
Species Human
Gene Type protein-coding
Description solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
Other Description apical iodide transporter|electrogenic sodium monocarboxylate cotransporter|sodium iodide-related cotransporter|sodium-coupled monocarboxylate transporter 1|solute carrier family 5 (iodide transporter), member 8|solute carrier family 5 member 8
Swissprots Q7Z2H9 Q2TB99 Q8N695
Accessions AAP46194 EAW97648 EAW97649 EAW97650 EAW97651 Q8N695 AF536216 AAP46193 AK075263 AK313788 BAG36525 AY081220 AAL88746 BC110492 AAI10493 XR_944503 XR_952100 NM_145913 NP_666018
Function Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and
Subcellular Location Apical cell membrane {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:15001644, ECO:0000269|PubMed:17245649}; Multi-pass membrane protein {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:15001644, ECO:0000269|PubMed:17245649}. Note=Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells. {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:15001644, ECO:0000269|PubMed:17245649}.
Tissue Specificity Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors. {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:12829793, ECO:0000269|PubMed:14966140, ECO:0000269|PubMed:15001644, ECO:0000269|PubMed:15090606, ECO:0000269|PubMed:15361710, ECO:0000269|PubMed:15867356, ECO:0000269|PubMed:17178845, ECO:0000269|PubMed:17245649, ECO:0000269|PubMed:18037591}.

solute carrier family 5 (iodide transporter) , member 8, ELISA Kit - MBS9324856 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 10pg/ml.
Range 62.5pg/ml-2000pg/ml.

Human SLC5A8 ELISA Kit - E097268 from Biobool

Category ELISA Kit

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9345710 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9348838 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9358784 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9353211 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9350351 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/ml
Range 0.25 ng/ml - 8 ng/ml

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9343733 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9356816 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9360788 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9345524 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9358770 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9354766 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9355915 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9368285 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9347079 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9359620 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9352318 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9373797 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9353146 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9347439 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9360471 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sodium-Coupled Monocarboxylate Transporter 1 (SLC5A8), ELISA Kit - MBS9367121 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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