SLC5A8

Gene Symbol SLC5A8
Entrez Gene 160728
Alt Symbol AIT, SMCT, SMCT1
Species Human
Gene Type protein-coding
Description solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
Other Description apical iodide transporter|electrogenic sodium monocarboxylate cotransporter|sodium iodide-related cotransporter|sodium-coupled monocarboxylate transporter 1|solute carrier family 5 (iodide transporter), member 8|solute carrier family 5 member 8
Swissprots Q7Z2H9 Q2TB99 Q8N695
Accessions AAP46194 EAW97648 EAW97649 EAW97650 EAW97651 Q8N695 AF536216 AAP46193 AK075263 AK313788 BAG36525 AY081220 AAL88746 BC110492 AAI10493 XR_944503 XR_952100 NM_145913 NP_666018
Function Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and
Subcellular Location Apical cell membrane {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:15001644, ECO:0000269|PubMed:17245649}; Multi-pass membrane protein {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:15001644, ECO:0000269|PubMed:17245649}. Note=Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells. {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:15001644, ECO:0000269|PubMed:17245649}.
Tissue Specificity Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors. {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:12829793, ECO:0000269|PubMed:14966140, ECO:0000269|PubMed:15001644, ECO:0000269|PubMed:15090606, ECO:0000269|PubMed:15361710, ECO:0000269|PubMed:15867356, ECO:0000269|PubMed:17178845, ECO:0000269|PubMed:17245649, ECO:0000269|PubMed:18037591}.

Human SLC5A8/SMCT1 (NP_666018) VersaClone cDNA - RDC0627 from R&D Systems

Prices $499.00
Sizes 10 µg
Species Human

SLC5A8 - MBS1273666 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC110492

human SLC5A8 ORF clone (NM_145913.3) - CDCH082772 from Creative biogene

Species Human

Human SLC5A8 ORF Clone (BC110492) - CDCS417055 from Creative biogene

Species Human
Accession Q8N695
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