| Gene Symbol |
FBXO45
|
| Entrez Gene |
200933
|
| Alt Symbol |
Fbx45
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box protein 45
|
| Other Description |
F-box only protein 45|F-box/SPRY domain-containing protein 1|hFbxo45
|
| Swissprots |
A6NF90 P0C2W1 D3DXB5
|
| Accessions |
EAW53643 EAW53644 P0C2W1 AK025697 BC172382 AAI72382 BE047625 BE778263 CA445163 DB636510 NM_001105573 NP_001099043
|
| Function |
Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. {ECO:0000250, ECO:0000269|PubMed:19581926}.
|
| Subcellular Location |
Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}.
|