Gene Symbol | FBXO45 |
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Entrez Gene | 200933 |
Alt Symbol | Fbx45 |
Species | Human |
Gene Type | protein-coding |
Description | F-box protein 45 |
Other Description | F-box only protein 45|F-box/SPRY domain-containing protein 1|hFbxo45 |
Swissprots | A6NF90 P0C2W1 D3DXB5 |
Accessions | EAW53643 EAW53644 P0C2W1 AK025697 BC172382 AAI72382 BE047625 BE778263 CA445163 DB636510 NM_001105573 NP_001099043 |
Function | Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. {ECO:0000250, ECO:0000269|PubMed:19581926}. |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. |
FBXO45 CRISPR/Cas9 KO Plasmid (h) - sc-417503 from Santa Cruz Biotechnology
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FBXO45 HDR Plasmid (h) - sc-417503-HDR from Santa Cruz Biotechnology
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FBXO45 Double Nickase Plasmid (h) - sc-417503-NIC from Santa Cruz Biotechnology
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FBXO45 Double Nickase Plasmid (h2) - sc-417503-NIC-2 from Santa Cruz Biotechnology
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FBXO45 CRISPR Activation Plasmid (h) - sc-417503-ACT from Santa Cruz Biotechnology
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FBXO45 CRISPR Activation Plasmid (h2) - sc-417503-ACT-2 from Santa Cruz Biotechnology
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FBXO45 Lentiviral Activation Particles (h) - sc-417503-LAC from Santa Cruz Biotechnology
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FBXO45 Lentiviral Activation Particles (h2) - sc-417503-LAC-2 from Santa Cruz Biotechnology
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FBXO45 siRNA (h) - sc-78222 from Santa Cruz Biotechnology
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FBXO45 shRNA Plasmid (h) - sc-78222-SH from Santa Cruz Biotechnology
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FBXO45 shRNA (h) Lentiviral Particles - sc-78222-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU034451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8561 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8561 from Sigma-Aldrich
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FBXO45 siRNA (Human) - CRJ6270 from Cohesion Biosciences
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FBXO45 - MBS828862 from MyBioSource
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shRNA set against Human Fbxo45 (NM_001105573.1) - SHH293353 from Creative biogene
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Human FBXO45 siRNA - orb276771 from Biorbyt
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FBXO45 shRNA Plasmid (Human) - CHJ6270 from Cohesion Biosciences
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