Gene Symbol | CFH |
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Entrez Gene | 3075 |
Alt Symbol | AHUS1, AMBP1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, HF1, HF2, HUS |
Species | Human |
Gene Type | protein-coding |
Description | complement factor H |
Other Description | H factor 1 (complement)|H factor 2 (complement)|adrenomedullin binding protein|age-related maculopathy susceptibility 1|beta-1-H-globulin|beta-1H|factor H|factor H-like 1 |
Swissprots | A5PL14 Q5TFM3 P78435 Q2TAZ5 Q14570 Q38G77 Q8N708 Q9NU86 P08603 |
Accessions | AAB01987 ABB02180 AGZ15310 AHH32464 CAA82763 EAW91260 EAW91261 P08603 AI568119 AK225649 AK226113 AK291395 BAF84084 BC012610 BC037285 AAH37285 BC073982 BC110643 AAI10644 BC142699 AAI42700 BM842566 BP324193 JF432152 ADZ15369 M12383 AAA52013 M17517 AAA52016 M65294 AAA35948 X04697 CAB41739 X07523 CAA30403 Y00716 CAA68704 NM_000186 NP_000177 NM_001014975 NP_001014975 |
Function | Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed by the liver and secreted in plasma. |
Top Pathways | Complement and coagulation cascades, Staphylococcus aureus infection |
Factor H CRISPR/Cas9 KO Plasmid (h) - sc-401099 from Santa Cruz Biotechnology
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Factor H HDR Plasmid (h) - sc-401099-HDR from Santa Cruz Biotechnology
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Factor H Double Nickase Plasmid (h) - sc-401099-NIC from Santa Cruz Biotechnology
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Factor H Double Nickase Plasmid (h2) - sc-401099-NIC-2 from Santa Cruz Biotechnology
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Factor H CRISPR Activation Plasmid (h) - sc-401099-ACT from Santa Cruz Biotechnology
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Factor H CRISPR Activation Plasmid (h2) - sc-401099-ACT-2 from Santa Cruz Biotechnology
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Factor H Lentiviral Activation Particles (h) - sc-401099-LAC from Santa Cruz Biotechnology
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Factor H Lentiviral Activation Particles (h2) - sc-401099-LAC-2 from Santa Cruz Biotechnology
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Factor H siRNA (h) - sc-42877 from Santa Cruz Biotechnology
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Factor H shRNA Plasmid (h) - sc-42877-SH from Santa Cruz Biotechnology
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Factor H shRNA (h) Lentiviral Particles - sc-42877-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU082061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5999 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5999 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01231 from Sigma-Aldrich
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CFH siRNA (Human) - CRH2095 from Cohesion Biosciences
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CFH - MBS8236718 from MyBioSource
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shRNA set against Human Cfh (NM_000186.3) - SHH262417 from Creative biogene
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CFH shRNA Plasmid (Human) - CHH2095 from Cohesion Biosciences
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CFH miRNA 3'UTR clone - MiUTR3H-00770 from Creative biogene
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CFH miRNA 3'UTR clone - MiUTR3H-00771 from Creative biogene
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