Gzma
| Gene Symbol | Gzma |
|---|---|
| Entrez Gene | 14938 |
| Alt Symbol | AW494114, Ctla-3, Ctla3, Hf, SE1, TSP-1, TSP1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | granzyme A |
| Other Description | BLT esterase|H factor|Hanukah factor|autocrine thymic lymphoma granzyme-like serine protease|fragmentin-1|serine esterase 1|t cell-specific serine protease 1 |
| Swissprots | P11032 P15118 |
| Accessions | AAA99897 AAA99898 CAA44426 EDL18394 EDL18395 EDL18396 P11032 AK146132 BAE26923 AK156728 BAE33822 BC061146 AAH61146 M13226 AAA40134 M26183 AAA37735 X14799 CAA32905 NM_010370 NP_034500 |
| Function | Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted. Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes. |
| Tissue Specificity | Found in cytotoxic lymphocytes and in normal lymphoid tissues such as thymus and spleen. |
| Top Pathways | Neuroactive ligand-receptor interaction |
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