Gene Symbol |
Gzma
|
Entrez Gene |
14938
|
Alt Symbol |
AW494114, Ctla-3, Ctla3, Hf, SE1, TSP-1, TSP1
|
Species |
Mouse
|
Gene Type |
protein-coding
|
Description |
granzyme A
|
Other Description |
BLT esterase|H factor|Hanukah factor|autocrine thymic lymphoma granzyme-like serine protease|fragmentin-1|serine esterase 1|t cell-specific serine protease 1
|
Swissprots |
P11032 P15118
|
Accessions |
AAA99897 AAA99898 CAA44426 EDL18394 EDL18395 EDL18396 P11032 AK146132 BAE26923 AK156728 BAE33822 BC061146 AAH61146 M13226 AAA40134 M26183 AAA37735 X14799 CAA32905 NM_010370 NP_034500
|
Function |
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity). {ECO:0000250}.
|
Subcellular Location |
Secreted. Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes.
|
Tissue Specificity |
Found in cytotoxic lymphocytes and in normal lymphoid tissues such as thymus and spleen.
|
Top Pathways |
Neuroactive ligand-receptor interaction
|