Gzma

Gene Symbol Gzma
Entrez Gene 14938
Alt Symbol AW494114, Ctla-3, Ctla3, Hf, SE1, TSP-1, TSP1
Species Mouse
Gene Type protein-coding
Description granzyme A
Other Description BLT esterase|H factor|Hanukah factor|autocrine thymic lymphoma granzyme-like serine protease|fragmentin-1|serine esterase 1|t cell-specific serine protease 1
Swissprots P11032 P15118
Accessions AAA99897 AAA99898 CAA44426 EDL18394 EDL18395 EDL18396 P11032 AK146132 BAE26923 AK156728 BAE33822 BC061146 AAH61146 M13226 AAA40134 M26183 AAA37735 X14799 CAA32905 NM_010370 NP_034500
Function Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity). {ECO:0000250}.
Subcellular Location Secreted. Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes.
Tissue Specificity Found in cytotoxic lymphocytes and in normal lymphoid tissues such as thymus and spleen.
Top Pathways Neuroactive ligand-receptor interaction

Mouse Gzma ORF Clone(NM_010370.2) - CDCR248876 from Creative Biomart

Species Mouse
Accession NM_010370.2

Mouse Gzma ORF Clone(NM_010370.2) - CDCR248877 from Creative Biomart

Species Mouse
Accession NM_010370.2

Mouse Gzma ORF Clone(NM_010370.2) - CDCL165651 from Creative Biomart

Species Mouse
Accession NM_010370.2

Human Gzma ORF clone (NM_010370.2) - CDCL115719 from Creative biogene

Species Mouse
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