| Gene Symbol |
CASP8AP2
|
| Entrez Gene |
9994
|
| Alt Symbol |
CED-4, FLASH, RIP25
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
caspase 8 associated protein 2
|
| Other Description |
CASP8 associated protein 2|CASP8-associated protein 2|FLASH homolog RIP25|FLICE associated huge|FLICE-associated huge protein|human FLASH
|
| Swissprots |
Q9UKL3 Q7LCQ7 Q6PH76 Q9P2N1 A2RUB7 Q86YD9 Q9Y563 Q9NZV9 E1P553 Q9NUQ4
|
| Accessions |
CCQ43107 EAW48540 EAW48541 EAW48542 EAW48543 EAW48544 Q9UKL3 AB037736 BAA92553 AF154415 AAF03367 AF164678 AAD45537 AF165161 AAD45157 AJ420582 AK002070 BAA92067 BC012574 BC027850 BC029386 BC042577 AAH42577 BC056685 AAH56685 BC132828 AAI32829 BC132830 AAI32831 BC150274 AAI50275 BP192859 BP363682 NM_001137667 NP_001131139 NM_001137668 NP_001131140 NM_012115 NP_036247
|
| Function |
Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation.
|