CASP8AP2

Gene Symbol CASP8AP2
Entrez Gene 9994
Alt Symbol CED-4, FLASH, RIP25
Species Human
Gene Type protein-coding
Description caspase 8 associated protein 2
Other Description CASP8 associated protein 2|CASP8-associated protein 2|FLASH homolog RIP25|FLICE associated huge|FLICE-associated huge protein|human FLASH
Swissprots Q9UKL3 Q7LCQ7 Q6PH76 Q9P2N1 A2RUB7 Q86YD9 Q9Y563 Q9NZV9 E1P553 Q9NUQ4
Accessions CCQ43107 EAW48540 EAW48541 EAW48542 EAW48543 EAW48544 Q9UKL3 AB037736 BAA92553 AF154415 AAF03367 AF164678 AAD45537 AF165161 AAD45157 AJ420582 AK002070 BAA92067 BC012574 BC027850 BC029386 BC042577 AAH42577 BC056685 AAH56685 BC132828 AAI32829 BC132830 AAI32831 BC150274 AAI50275 BP192859 BP363682 NM_001137667 NP_001131139 NM_001137668 NP_001131140 NM_012115 NP_036247
Function Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.
Subcellular Location Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation.

FLASH CRISPR/Cas9 KO Plasmid (h) - sc-403170 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLASH HDR Plasmid (h) - sc-403170-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLASH Double Nickase Plasmid (h) - sc-403170-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLASH Double Nickase Plasmid (h2) - sc-403170-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLASH CRISPR Activation Plasmid (h) - sc-403170-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLASH CRISPR Activation Plasmid (h2) - sc-403170-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLASH Lentiviral Activation Particles (h) - sc-403170-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLASH Lentiviral Activation Particles (h2) - sc-403170-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLASH siRNA (h) - sc-43761 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FLASH shRNA Plasmid (h) - sc-43761-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FLASH shRNA (h) Lentiviral Particles - sc-43761-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU044071 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5389 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5389 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06621 from Sigma-Aldrich

Category miRNA

CASP8AP2 siRNA (Human) - CRH6726 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CASP8AP2 - MBS8212022 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CASP8AP2 (NM_012115.3) - SHH255037 from Creative biogene

Category siRNA
Species Reactivities Human

Human CASP8AP2 siRNA - orb267228 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CASP8AP2 shRNA Plasmid (Human) - CHH6726 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CASP8AP2 miRNA 3'UTR clone - MiUTR3H-08791 from Creative biogene

Species Reactivities Human

CASP8AP2 miRNA 3'UTR clone - MiUTR3H-08792 from Creative biogene

Species Reactivities Human

CASP8AP2 miRNA 3'UTR clone - MiUTR3H-08793 from Creative biogene

Species Reactivities Human
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