CASP8AP2

Gene Symbol	CASP8AP2
Entrez Gene	9994
Alt Symbol	CED-4, FLASH, RIP25
Species	Human
Gene Type	protein-coding
Description	caspase 8 associated protein 2
Other Description	CASP8 associated protein 2|CASP8-associated protein 2|FLASH homolog RIP25|FLICE associated huge|FLICE-associated huge protein|human FLASH
Swissprots	Q9UKL3 Q7LCQ7 Q6PH76 Q9P2N1 A2RUB7 Q86YD9 Q9Y563 Q9NZV9 E1P553 Q9NUQ4
Accessions	CCQ43107 EAW48540 EAW48541 EAW48542 EAW48543 EAW48544 Q9UKL3 AB037736 BAA92553 AF154415 AAF03367 AF164678 AAD45537 AF165161 AAD45157 AJ420582 AK002070 BAA92067 BC012574 BC027850 BC029386 BC042577 AAH42577 BC056685 AAH56685 BC132828 AAI32829 BC132830 AAI32831 BC150274 AAI50275 BP192859 BP363682 NM_001137667 NP_001131139 NM_001137668 NP_001131140 NM_012115 NP_036247
Function	Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.
Subcellular Location	Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FLASH peptide - ab8455 from Abcam Category Peptide Species Human

CASP8AP2 / FLASH Antibody Blocking Peptide - LS-E18251 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CASP8AP2 / FLASH Antibody Blocking Peptide - LS-E29933 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FLASH Blocking Peptide - NBP1-77301PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

FLASH peptide - GTX28455 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

CASP8AP2 Blocking Peptide - 33R-8602 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CASP8AP2 / FLASH Control Peptide - AP30339CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

FLASH Peptide - 2271P from ProSci Category Peptide Species Human

CASP8AP2 fusion protein - ag19912 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

CASP8AP2 fusion protein - ag19738 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Caspase 8 Associated Protein 2 (CASP8AP2) - RPJ487Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Human CASP8-associated protein 2(CASP8AP2) ,partial - CSB-YP890737HU CSB-EP890737HU CSB-BP890737HU CSB-MP890737HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CASP8-associated protein 2 (CASP8AP2), partial, Recombinant Protein - MBS1308728 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Synthetic Human CASP8AP2 (aa 1253-1268)(CT) Blocking Peptide - PX046BP from Cell Science Category Peptide Prices $170.00 Sizes 50 μg Species Human

CASP8AP2 Peptide, Human - M34GP02400H from Creative Peptides Category Peptide Source Synthetic. Species Human

FLASH Recombinant Protein Antigen - NBP2-58151PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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