| Gene Symbol |
RAD21
|
| Entrez Gene |
5885
|
| Alt Symbol |
CDLS4, HR21, HRAD21, MCD1, NXP1, SCC1, hHR21
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAD21 homolog (S. pombe)
|
| Other Description |
NXP-1|SCC1 homolog|double-strand-break repair protein rad21 homolog|nuclear matrix protein 1|protein involved in DNA double-strand break repair|sister chromatid cohesion 1
|
| Swissprots |
O60216 Q99568 Q15001 A8K0E0
|
| Accessions |
AAT70725 EAW91963 EAW91964 EAW91965 O60216 AK097915 BAG53550 AK098521 AK125620 AK289505 BAF82194 BC001229 BC050381 AAH50381 D38551 BAA07554 DA328186 X98294 CAA66940 NM_006265 NP_006256
|
| Function |
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}.
|
| Subcellular Location |
Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, it is cleaved by separase/ESPL1, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. Once cleaved by caspase-3, the C-terminal 64 kDa cleavage product translocates to the cytoplasm, where it may trigger apoptosis.
|
| Top Pathways |
Cell cycle
|