RAD21

Gene Symbol	RAD21
Entrez Gene	5885
Alt Symbol	CDLS4, HR21, HRAD21, MCD1, NXP1, SCC1, hHR21
Species	Human
Gene Type	protein-coding
Description	RAD21 homolog (S. pombe)
Other Description	NXP-1|SCC1 homolog|double-strand-break repair protein rad21 homolog|nuclear matrix protein 1|protein involved in DNA double-strand break repair|sister chromatid cohesion 1
Swissprots	O60216 Q99568 Q15001 A8K0E0
Accessions	AAT70725 EAW91963 EAW91964 EAW91965 O60216 AK097915 BAG53550 AK098521 AK125620 AK289505 BAF82194 BC001229 BC050381 AAH50381 D38551 BAA07554 DA328186 X98294 CAA66940 NM_006265 NP_006256
Function	Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}.
Subcellular Location	Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, it is cleaved by separase/ESPL1, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. Once cleaved by caspase-3, the C-terminal 64 kDa cleavage product translocates to the cytoplasm, where it may trigger apoptosis.
Top Pathways	Cell cycle

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Rad21 full length protein - ab152647 from Abcam Category Protein Source Wheat germ Species Human

Human Rad21 peptide - ab42520 from Abcam Category Peptide

Human Rad21 peptide - ab42521 from Abcam Category Peptide

RAD21 Antibody Blocking Peptide - LS-E20633 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAD21 Antibody Blocking Peptide - LS-E20632 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Rad21 Protein - H00005885-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Rad21 Blocking Peptide - 33R-3070 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Rad21 Blocking Peptide - 33R-2307 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RAD21 - H00005885-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Rad21 (D548) Peptide - BS2422P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Double-strand-break repair protein rad21 homolog(RAD21) - CSB-YP019257HU CSB-EP019257HU CSB-BP019257HU CSB-MP019257HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Rad21 Recombinant Protein Antigen - NBP1-83260PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RAD21 Blocking Peptide - abx061075 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Zebrafish

RAD21-Antibody-C-term-Blocking-Peptide - BP7396b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RAD21 Peptide, Human - M34GP12906H from Creative Peptides Category Peptide Source Synthetic. Species Human

RAD21 Blocking Peptide - CBP4988 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Zebrafish

Double-strand-break repair protein rad21 homolog (RAD21), Recombinant Protein - MBS1142481 from MyBioSource Category Protein Prices $1,425.00, $1,425.00, $1,655.00, $1,655.00, $2,415.00, $2,415.00, $2,860.00, $2,860.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RAD21 fusion protein - Ag25481 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

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