Gene Symbol | FCN2 |
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Entrez Gene | 2220 |
Alt Symbol | EBP-37, FCNL, P35, ficolin-2 |
Species | Human |
Gene Type | protein-coding |
Description | ficolin (collagen/fibrinogen domain containing lectin) 2 |
Other Description | 37 kDa elastin-binding protein|L-ficolin|collagen/fibrinogen domain-containing protein 2|ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)|ficolin B|ficolin-2|ficolin-B|ficolin-beta|serum lectin p35 |
Swissprots | Q9UC57 Q15485 A6NFG7 Q6IS69 A8K478 Q7M4P4 |
Accessions | ABB01005 BAA09636 EAW88133 EAW88134 EAW88135 EAW88136 Q15485 AI052239 AK096112 AK290843 BAF83532 AK308476 BC069572 AAH69572 BC069825 AAH69825 BC113935 AAI13936 D49353 BAA08352 JB054537 CCV66758 XM_006717015 XP_006717078 XM_011518392 XP_011516694 NM_004108 NP_004099 NM_015837 NP_056652 NM_015838 NM_015839 |
Function | May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. {ECO:0000269|PubMed:10679061}. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed by the liver and secreted in plasma. |
L-ficolin CRISPR/Cas9 KO Plasmid (h) - sc-404837 from Santa Cruz Biotechnology
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L-ficolin HDR Plasmid (h) - sc-404837-HDR from Santa Cruz Biotechnology
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L-ficolin Double Nickase Plasmid (h) - sc-404837-NIC from Santa Cruz Biotechnology
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L-ficolin Double Nickase Plasmid (h2) - sc-404837-NIC-2 from Santa Cruz Biotechnology
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L-ficolin CRISPR Activation Plasmid (h) - sc-404837-ACT from Santa Cruz Biotechnology
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L-ficolin CRISPR Activation Plasmid (h2) - sc-404837-ACT-2 from Santa Cruz Biotechnology
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L-ficolin Lentiviral Activation Particles (h) - sc-404837-LAC from Santa Cruz Biotechnology
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L-ficolin Lentiviral Activation Particles (h2) - sc-404837-LAC-2 from Santa Cruz Biotechnology
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L-ficolin siRNA (h) - sc-105603 from Santa Cruz Biotechnology
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L-ficolin shRNA Plasmid (h) - sc-105603-SH from Santa Cruz Biotechnology
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L-ficolin shRNA (h) Lentiviral Particles - sc-105603-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN8600 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8600 from Sigma-Aldrich
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FCN2 siRNA (Human) - CRH1553 from Cohesion Biosciences
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Ficolin-2 RNAi - H00002220-R01 from Novus Biologicals
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Ficolin-2 RNAi - H00002220-R02 from Novus Biologicals
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FCN2 - MBS8231756 from MyBioSource
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shRNA set against Human FCN2 (NM_004108.2) - SHH293829 from Creative biogene
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shRNA set against Human FCN2(NM_015837.2) - SHH054857 from Creative biogene
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Human FCN2 siRNA - orb262055 from Biorbyt
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FCN2 shRNA Plasmid (Human) - CHH1553 from Cohesion Biosciences
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FCN2 miRNA 3'UTR clone - MiUTR1H-03597 from Creative biogene
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FCN2 miRNA 3'UTR clone - MiUTR1H-03598 from Creative biogene
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