Gene Symbol | RABAC1 |
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Entrez Gene | 10567 |
Alt Symbol | PRA1, PRAF1, YIP3 |
Species | Human |
Gene Type | protein-coding |
Description | Rab acceptor 1 (prenylated) |
Other Description | PRA1 domain family 1|PRA1 family protein 1|prenylated Rab acceptor 1|prenylated Rab acceptor protein 1 |
Swissprots | Q9UI14 Q7Z4Y2 Q9Y3R1 |
Accessions | EAW57086 EAW57087 EAW57088 Q9UI14 AF112202 AAF17190 AF112996 AAP97229 AI376198 AJ133534 CAB43107 BC008950 AAH08950 BT019964 AAV38767 CF242972 CR457214 CAG33495 CR542116 CAG46913 DB454056 NM_006423 NP_006414 |
Function | General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Note=According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles. {ECO:0000250}. |
Tissue Specificity | Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach. {ECO:0000269|PubMed:11520070}. |
PRA1 CRISPR/Cas9 KO Plasmid (h) - sc-404295 from Santa Cruz Biotechnology
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PRA1 HDR Plasmid (h) - sc-404295-HDR from Santa Cruz Biotechnology
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PRA1 Double Nickase Plasmid (h) - sc-404295-NIC from Santa Cruz Biotechnology
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PRA1 Double Nickase Plasmid (h2) - sc-404295-NIC-2 from Santa Cruz Biotechnology
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PRA1 CRISPR Activation Plasmid (h) - sc-404295-ACT from Santa Cruz Biotechnology
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PRA1 CRISPR Activation Plasmid (h2) - sc-404295-ACT-2 from Santa Cruz Biotechnology
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PRA1 Lentiviral Activation Particles (h) - sc-404295-LAC from Santa Cruz Biotechnology
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PRA1 Lentiviral Activation Particles (h2) - sc-404295-LAC-2 from Santa Cruz Biotechnology
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PRA1 siRNA (h) - sc-97561 from Santa Cruz Biotechnology
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PRA1 shRNA Plasmid (h) - sc-97561-SH from Santa Cruz Biotechnology
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PRA1 shRNA (h) Lentiviral Particles - sc-97561-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU153541 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17872 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17872 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00300 from Sigma-Aldrich
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RABAC1 siRNA (Human) - CRH7188 from Cohesion Biosciences
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RABAC1 - MBS8235633 from MyBioSource
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shRNA set against Human RABAC1 (NM_006423.2) - SHH388656 from Creative biogene
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Human RABAC1 siRNA - orb267690 from Biorbyt
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RABAC1 shRNA Plasmid (Human) - CHH7188 from Cohesion Biosciences
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RABAC1 miRNA 3'UTR clone - MiUTR3H-07212 from Creative biogene
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