LIG3

Gene Symbol LIG3
Entrez Gene 3980
Alt Symbol LIG2
Species Human
Gene Type protein-coding
Description ligase III, DNA, ATP-dependent
Other Description DNA ligase 3|ligase II, DNA, ATP-dependent|polydeoxyribonucleotide synthase [ATP] 3
Swissprots E5KLB6 Q16714 P49916 Q6NVK3 E5KLB5
Accessions AAL91592 ADP89974 ADP89975 ADP89976 ADP89977 ADP89978 ADP89979 ADP89980 ADP89981 ADP89982 ADP89983 ADP89984 ADP89985 ADP89986 ADP89987 ADP89988 ADP89989 ADP89990 ADP89991 ADP89992 ADP89993 ADP89994 ADP89995 ADP89996 ADP89997 ADP89998 ADP89999 ADP90000 ADP90001 ADP90002 ADP90003 ADP90004 ADP90005 ADP90006 ADP90007 ADP90008 ADP90009 ADP90010 ADP90011 ADP90012 ADP90013 ADP90014 ADP90015 ADP90016 ADP90017 ADP90018 ADP90019 ADP90020 ADP90021 ADP90022 ADP90023 ADP90024 ADP90025 ADP90026 ADP90027 ADP90028 ADP90029 ADP90030 ADP90031 ADP90032 ADP90033 ADP90034 ADP90035 ADP90036 ADP90037 ADP90038 ADP90039 ADP90040 ADP90041 ADP90042 ADP90043 ADP90044 ADP90045 ADP90046 ADP90047 ADP90048 ADP90049 ADP90050 ADP90051 ADP90052 ADP90053 BAH59593 EAW80197 EAW80198 EAW80199 P49916 AA872458 AK125853 AK300363 BAH13269 AK308407 AW166526 BC009026 AAH09026 BC068005 AAH68005 BG470103 BM467239 BM726768 BM759573 DB100562 U40671 AAA85022 X84740 CAA59230 XM_005257970 XP_005258027 XM_006721896 XP_006721959 XM_011524797 XP_011523099 XM_011524798 XP_011523100 XM_011524799 XP_011523101 XM_011524800 XP_011523102 NM_002311 NP_002302 NM_013975 NP_039269
Function Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}.
Subcellular Location Isoform 3: Nucleus {ECO:0000269|PubMed:10207110}. Note=Lacks the N-terminal mitochondrial transit peptide. {ECO:0000269|PubMed:10207110}.
Tissue Specificity Testis, thymus, prostate and heart.
Top Pathways Base excision repair

Human DNA Ligase III protein fragment - ab91933 from Abcam

Category Protein
Source E. coli
Species Human
The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images coloured control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.

LIG3-Antibody-C-term-Blocking-Peptide - BP16089b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

DNA ligase 3 - H00003980-P01 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Species Human

DNA ligase 3 - H00003980-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

DNA ligase 3 - H00003980-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

LIG3 fusion protein - ag10401 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

LIG3 fusion protein - ag10388 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

Recombinant Human LIG3, His-tagged - LIG3-26931TH from Creative Biomart

Category Protein
Source E. coli

Recombinant Human DNA ligase 3(LIG3) ,partial - CSB-YP012931HU CSB-EP012931HU CSB-BP012931HU CSB-MP012931HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

DNA ligase 3 (transcript variant alpha) - TP309530 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
DNA ligase 3

DNA Ligase 3 Blocking Peptide - abx061812 from Abbexa

Category Peptide

DNA Ligase 3 Blocking Peptide - CBP7202 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse

DNA ligase 3 (LIG3), partial, Recombinant Protein - MBS964883 from MyBioSource

Category Protein
Prices $880.00, $880.00, $1,105.00, $1,105.00, $1,265.00, $1,265.00, $1,710.00, $1,710.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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