| Gene Symbol | LIG3 |
|---|---|
| Entrez Gene | 3980 |
| Alt Symbol | LIG2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ligase III, DNA, ATP-dependent |
| Other Description | DNA ligase 3|ligase II, DNA, ATP-dependent|polydeoxyribonucleotide synthase [ATP] 3 |
| Swissprots | E5KLB6 Q16714 P49916 Q6NVK3 E5KLB5 |
| Accessions | AAL91592 ADP89974 ADP89975 ADP89976 ADP89977 ADP89978 ADP89979 ADP89980 ADP89981 ADP89982 ADP89983 ADP89984 ADP89985 ADP89986 ADP89987 ADP89988 ADP89989 ADP89990 ADP89991 ADP89992 ADP89993 ADP89994 ADP89995 ADP89996 ADP89997 ADP89998 ADP89999 ADP90000 ADP90001 ADP90002 ADP90003 ADP90004 ADP90005 ADP90006 ADP90007 ADP90008 ADP90009 ADP90010 ADP90011 ADP90012 ADP90013 ADP90014 ADP90015 ADP90016 ADP90017 ADP90018 ADP90019 ADP90020 ADP90021 ADP90022 ADP90023 ADP90024 ADP90025 ADP90026 ADP90027 ADP90028 ADP90029 ADP90030 ADP90031 ADP90032 ADP90033 ADP90034 ADP90035 ADP90036 ADP90037 ADP90038 ADP90039 ADP90040 ADP90041 ADP90042 ADP90043 ADP90044 ADP90045 ADP90046 ADP90047 ADP90048 ADP90049 ADP90050 ADP90051 ADP90052 ADP90053 BAH59593 EAW80197 EAW80198 EAW80199 P49916 AA872458 AK125853 AK300363 BAH13269 AK308407 AW166526 BC009026 AAH09026 BC068005 AAH68005 BG470103 BM467239 BM726768 BM759573 DB100562 U40671 AAA85022 X84740 CAA59230 XM_005257970 XP_005258027 XM_006721896 XP_006721959 XM_011524797 XP_011523099 XM_011524798 XP_011523100 XM_011524799 XP_011523101 XM_011524800 XP_011523102 NM_002311 NP_002302 NM_013975 NP_039269 |
| Function | Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| Subcellular Location | Isoform 3: Nucleus {ECO:0000269|PubMed:10207110}. Note=Lacks the N-terminal mitochondrial transit peptide. {ECO:0000269|PubMed:10207110}. |
| Tissue Specificity | Testis, thymus, prostate and heart. |
| Top Pathways | Base excision repair |
DNA Ligase III CRISPR/Cas9 KO Plasmid (h) - sc-402841 from Santa Cruz Biotechnology
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DNA Ligase III HDR Plasmid (h) - sc-402841-HDR from Santa Cruz Biotechnology
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DNA Ligase III Double Nickase Plasmid (h) - sc-402841-NIC from Santa Cruz Biotechnology
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DNA Ligase III Double Nickase Plasmid (h2) - sc-402841-NIC-2 from Santa Cruz Biotechnology
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DNA Ligase III CRISPR Activation Plasmid (h) - sc-402841-ACT from Santa Cruz Biotechnology
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DNA Ligase III CRISPR Activation Plasmid (h2) - sc-402841-ACT-2 from Santa Cruz Biotechnology
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DNA Ligase III Lentiviral Activation Particles (h) - sc-402841-LAC from Santa Cruz Biotechnology
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DNA Ligase III Lentiviral Activation Particles (h2) - sc-402841-LAC-2 from Santa Cruz Biotechnology
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DNA Ligase III siRNA (h) - sc-72079 from Santa Cruz Biotechnology
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DNA Ligase III shRNA Plasmid (h) - sc-72079-SH from Santa Cruz Biotechnology
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DNA Ligase III shRNA (h) Lentiviral Particles - sc-72079-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU090491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11704 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11704 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04284 from Sigma-Aldrich
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LIG3 siRNA (Human) - CRH2693 from Cohesion Biosciences
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shRNA set against Human LIG3 (NM_002311.4) - SHH330239 from Creative biogene
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LIG3 shRNA Plasmid (Human) - CHH2693 from Cohesion Biosciences
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LIG3 miRNA 3'UTR clone - MiUTR1H-05668 from Creative biogene
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LIG3 miRNA 3'UTR clone - MiUTR3H-03760 from Creative biogene
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