LIG3

Gene Symbol	LIG3
Entrez Gene	3980
Alt Symbol	LIG2
Species	Human
Gene Type	protein-coding
Description	ligase III, DNA, ATP-dependent
Other Description	DNA ligase 3|ligase II, DNA, ATP-dependent|polydeoxyribonucleotide synthase [ATP] 3
Swissprots	E5KLB6 Q16714 P49916 Q6NVK3 E5KLB5
Accessions	AAL91592 ADP89974 ADP89975 ADP89976 ADP89977 ADP89978 ADP89979 ADP89980 ADP89981 ADP89982 ADP89983 ADP89984 ADP89985 ADP89986 ADP89987 ADP89988 ADP89989 ADP89990 ADP89991 ADP89992 ADP89993 ADP89994 ADP89995 ADP89996 ADP89997 ADP89998 ADP89999 ADP90000 ADP90001 ADP90002 ADP90003 ADP90004 ADP90005 ADP90006 ADP90007 ADP90008 ADP90009 ADP90010 ADP90011 ADP90012 ADP90013 ADP90014 ADP90015 ADP90016 ADP90017 ADP90018 ADP90019 ADP90020 ADP90021 ADP90022 ADP90023 ADP90024 ADP90025 ADP90026 ADP90027 ADP90028 ADP90029 ADP90030 ADP90031 ADP90032 ADP90033 ADP90034 ADP90035 ADP90036 ADP90037 ADP90038 ADP90039 ADP90040 ADP90041 ADP90042 ADP90043 ADP90044 ADP90045 ADP90046 ADP90047 ADP90048 ADP90049 ADP90050 ADP90051 ADP90052 ADP90053 BAH59593 EAW80197 EAW80198 EAW80199 P49916 AA872458 AK125853 AK300363 BAH13269 AK308407 AW166526 BC009026 AAH09026 BC068005 AAH68005 BG470103 BM467239 BM726768 BM759573 DB100562 U40671 AAA85022 X84740 CAA59230 XM_005257970 XP_005258027 XM_006721896 XP_006721959 XM_011524797 XP_011523099 XM_011524798 XP_011523100 XM_011524799 XP_011523101 XM_011524800 XP_011523102 NM_002311 NP_002302 NM_013975 NP_039269
Function	Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}.
Subcellular Location	Isoform 3: Nucleus {ECO:0000269|PubMed:10207110}. Note=Lacks the N-terminal mitochondrial transit peptide. {ECO:0000269|PubMed:10207110}.
Tissue Specificity	Testis, thymus, prostate and heart.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DNA Ligase III (H-300) - sc-292772 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

DNA Ligase III (6G9) - sc-56089 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

DNA Ligase III (7) - sc-135883 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

DNA Ligase III (E-7) - sc-390922 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-DNA Ligase III antibody - ab185815 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DNA Ligase III antibody - ab96576 from Abcam Prices $384.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-DNA Ligase III antibody - ab123874 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DNA Ligase III antibody - ab125434 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DNA Ligase III antibody [1F3] - ab36499 from Abcam Prices $372.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 1F3

Anti-DNA Ligase III antibody [6G9] - ab587 from Abcam Prices $400.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 6G9

Anti-LIG3 / DNA Ligase III Antibody (clone 1F3) - LS-C19960 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1F3

Anti-LIG3 / DNA Ligase III Antibody (clone 6G9) - LS-C19964 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 6G9

Anti-LIG3 / DNA Ligase III Antibody (aa1-919, clone 4H9) - LS-C53375 from LifeSpan Bioscience Prices $445.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 4H9

Anti-LIG3 / DNA Ligase III Antibody (aa1-862, clone 4H9) - LS-C53376 from LifeSpan Bioscience Prices $445.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 4H9

Anti-LIG3 / DNA Ligase III Antibody (aa1-862) - LS-C83543 from LifeSpan Bioscience Prices $415.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-LIG3 / DNA Ligase III Antibody (aa792-822, AP) - LS-C223046 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIG3 / DNA Ligase III Antibody (aa792-822, APC) - LS-C226827 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIG3 / DNA Ligase III Antibody (aa792-822, Biotin) - LS-C226828 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIG3 / DNA Ligase III Antibody (aa792-822, FITC) - LS-C226829 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIG3 / DNA Ligase III Antibody (aa792-822, Azide-free, HRP) - LS-C226830 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIG3 / DNA Ligase III Antibody (aa930-979) - LS-C146277 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-LIG3 / DNA Ligase III Antibody (aa792-822, PE) - LS-C226831 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIG3 / DNA Ligase III Antibody (aa220-269) - LS-C135328 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-LIG3 / DNA Ligase III Antibody (aa800-850) - LS-C288428 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LIG3 / DNA Ligase III Antibody (aa792-822) - LS-C329768 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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