YWHAB

Gene Symbol	YWHAB
Entrez Gene	7529
Alt Symbol	GW128, HEL-S-1, HS1, KCIP-1, YWHAA
Species	Human
Gene Type	protein-coding
Description	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Other Description	14-3-3 alpha|14-3-3 protein beta/alpha|brain protein 14-3-3, beta isoform|epididymis secretory protein Li 1|protein 1054|protein kinase C inhibitor protein 1|protein kinase C inhibitor protein-1|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Swissprots	E1P616 A8K9K2 P31946
Accessions	EAW75893 EAW75894 EAW75895 EAW75896 P31946 AA845374 AB209759 BAD92996 AB451260 BAG70074 AB451386 BAG70200 AF064847 AF107406 AAD44524 AK292717 BAF85406 AL834170 BC001359 AAH01359 BC010352 BF316820 DB443535 EU794580 ACJ13634 EU832334 ACE87591 EU832419 ACE86904 X57346 CAA40621 NM_003404 NP_003395 NM_139323 NP_647539
Function	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways	Cell cycle, Oocyte meiosis, Viral carcinogenesis, PI3K-Akt signaling pathway, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

YWHAB-Over-expression-Lysate - LY11072a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

YWHAB 293 Cell Lysate - 408721 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

YWHAB 293 Cell Lysate - 402935 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

14-3-3 beta/alpha Overexpression Lysate (Native) - NBL1-17946 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

14-3-3 beta/alpha Overexpression Lysate (Native) - NBL1-17947 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

14-3-3 β (h): 293T Lysate - sc-176767 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

14-3-3 β (h2): 293T Lysate - sc-176768 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

YWHAB Over-expression Lysate Product - GWB-992EF4 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

YWHAB Over-expression Lysate Product - GWB-819B6E from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human YWHAB Knockdown Stable Cell Line - CSC-DC017643 from Creative biogene Category Cell Line Species Human

YWHAB Knockout Cell Line-HeLa - CSC-RT2075 from Creative biogene Category Cell Line Species Human

YWHAB KO Cell Lysate-HeLa - CLKO-1936 from Creative biogene Category Cell Lysate

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