YWHAB

Gene Symbol YWHAB
Entrez Gene 7529
Alt Symbol GW128, HEL-S-1, HS1, KCIP-1, YWHAA
Species Human
Gene Type protein-coding
Description tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Other Description 14-3-3 alpha|14-3-3 protein beta/alpha|brain protein 14-3-3, beta isoform|epididymis secretory protein Li 1|protein 1054|protein kinase C inhibitor protein 1|protein kinase C inhibitor protein-1|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Swissprots E1P616 A8K9K2 P31946
Accessions EAW75893 EAW75894 EAW75895 EAW75896 P31946 AA845374 AB209759 BAD92996 AB451260 BAG70074 AB451386 BAG70200 AF064847 AF107406 AAD44524 AK292717 BAF85406 AL834170 BC001359 AAH01359 BC010352 BF316820 DB443535 EU794580 ACJ13634 EU832334 ACE87591 EU832419 ACE86904 X57346 CAA40621 NM_003404 NP_003395 NM_139323 NP_647539
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways Cell cycle, Oocyte meiosis, Viral carcinogenesis, PI3K-Akt signaling pathway, Epstein-Barr virus infection

14-3-3 β/α Antibody - 9636 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa, NIH/3T3, and C6 cells using 14-3-3 β/α Antibody.

14-3-3 β (A-6) - sc-25276 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
14-3-3 β (A-6): sc-25276. Western blot analysis of 14-3-3 β expression in A-431 (A), K-562 (B), NIH/3T3 (C) and KNRK (D) whole cell lysates.

14-3-3 β (C-20) - sc-628 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
14-3-3 β (C-20): sc-628. Western blot analysis of 14-3-3 β expression in A-431 (A), K-562 (B), U-937 (C) and NIH/3T3 (D) whole cell lysates.

14-3-3 β (A-15) - sc-17288 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
14-3-3 β (A-15): sc-17288. Western blot analysis of 14-3-3 β expression in SK-N-MC whole cell lysate.

14-3-3 β (60C10) - sc-59419 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
14-3-3 β (60C10): sc-59419. Western blot analysis of 14-3-3 β expression in K-562 (A), HeLa (B), NIH/3T3 (C), PC-12 (D), U-937 (E) and A-431 (F) whole cell lysates.

pan 14-3-3 (K-19) - sc-629 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
pan 14-3-3 (K-19): sc-629. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver tumor showing cytoplasmic staining of hepatocytes.

pan 14-3-3 (B-8) - sc-133233 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
pan 14-3-3 (B-8): sc-133233. Immunoperoxidase staining of formalin fixed, paraffin-embedded human urinary bladder tissue showing cytoplasmic and nuclear staining of urothelial cells.

pan-14-3-3 (FL-246) - sc-13959 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
14-3-3 β siRNA (h): sc-29186. Immunofluorescence staining of methanol-fixed, control HeLa (A) and 14-3-3 β siRNA silenced HeLa (B) cells showing diminished cytoplasmic staining in the siRNA silenced cells. Cells probed with 14-3-3 β (FL-246): sc-13959.

pan 14-3-3 (B-11) - sc-133232 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
pan 14-3-3 (B-11): sc-133232. Immunoperoxidase staining of formalin fixed, paraffin-embedded human rectum tissue showing cytoplasmic staining of glandular cells.

pan 14-3-3 (H-8) - sc-1657 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
pan 14-3-3 (H-8): sc-1657. Immunofluorescence stain-ing of methanol-fixed HeLa cells. Note cytoplasmic fluorescein immunostaining and nuclear DAPI counterstain.

pan 14-3-3 (F-1) - sc-166061 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
pan 14-3-3 (F-1): sc-166061. Western blot analysis of 14-3-3 ζ expression in non-transfected 293T: sc-117752 (A), human 14-3-3 ζ transfected 293T: sc-111414 (B) and HeLa (C) whole cell lysates.

Anti-14-3-3 alpha + beta antibody - ab113769 from Abcam

Prices $407.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-14-3-3 alpha + beta antibody (ab113769) at 1/1000 dilution + Raji whole cell lysate at 30 µg

Anti-14-3-3 alpha + beta antibody - ab37550 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-14-3-3 alpha + beta antibody (ab37550) at 1/100 dilution + Jurkat cell lysate

Anti-14-3-3 alpha + beta antibody [Y62] - ab32560 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y62
Anti-14-3-3 alpha + beta antibody [Y62] (ab32560) at 1/1000 dilution + Hela cell lysate.

Anti-14-3-3 antibody - ab9063 from Abcam

Prices $401.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-14-3-3 antibody (ab9063) at 1/1000 dilutionLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Lung (Human) Tissue Lysate Lane 3 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-14-3-3 antibody - ab6081 from Abcam

Prices $379.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal
All lanes : Anti-14-3-3 antibody (ab6081) at 1/200 dilutionLane 1 : Spinal Cord (Mouse) Tissue Lysate Lane 2 : Lung (Rat) Tissue Lysate Lane 3 : Lung (Mouse) Whole Cell Lysate - normal tissue (ab29297)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-14-3-3 antibody - ab30579 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-14-3-3 antibody (ab30579) at 1/1000 dilution + rat brain hippocampus lysate

Anti-14-3-3 antibody [3F7] - ab14110 from Abcam

Prices $388.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 3F7
In the confocal image above are two rat Glia cells side by side with the nuclei labelled with a blue counterstain. Anti-14-3-3 (ab14110) is in red and shows cytosolic and some nuclear localisation. 63x objective, 4x zoom. Image courtesy of Randal Moldrich (submitted as an abreview).

Anti-14-3-3 antibody [3F7] - ab14108 from Abcam

Prices $370.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 3F7

Anti-14-3-3 antibody [60C10] - ab133758 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 60C10
Immunohistochemical analysis of formalin-fixed, paraffin embedded Human tonsil tissue labelling 14-3-3 with ab133758 at a 1/200 dilution followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-14-3-3 antibody [EPR5872] - ab133538 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5872
All lanes : Anti-14-3-3 antibody [EPR5872] (ab133538) at 1/1000 dilutionLane 1 : Human fetal lung lysateLane 2 : A549 cell lysateLane 3 : Human kidney lysateLane 4 : Human spleen lysateLysates/proteins at 10 µg per lane.SecondaryHRP-labelled Goat anti-Rabbit at 1/2000 dilution

Anti-14-3-3 antibody [EPR6379] - ab133323 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6379
All lanes : Anti-14-3-3 antibody [EPR6379] (ab133323) at 1/50000 dilutionLane 1 : HeLa cell lysateLane 2 : SH-SY5Y cell lysateLane 3 : Raji cell lysateLane 4 : HepG2 cell lysateLane 5 : C6 cell lysateLane 6 : Raw264.7 cell lysateLane 7 : PC-12 cell lysateLane 8 : NIH/3T3 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-14-3-3 antibody [EPR6380] - ab125032 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6380
All lanes : Anti-14-3-3 antibody [EPR6380] (ab125032) at 1/1000 dilutionLane 1 : Hela cell lysateLane 2 : SH-SY5Y cell lysateLane 3 : Raji cell lysateLane 4 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti rabbit at 1/2000 dilution

Anti-14-3-3 beta + epsilon + zeta antibody [3C8] - ab115176 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C8
All lanes : Anti-14-3-3 beta + epsilon + zeta antibody [3C8] (ab115176) at 10 µg/mlLane 1 : HeLa whole cell extractLane 2 : Mouse brain extractLane 3 : Rat brain extract

Anti-14-3-3 beta + zeta (phospho S184 + S186) antibody - ab111856 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-14-3-3 beta + zeta (phospho S184 + S186) antibody (ab111856) at 1/500 dilutionLane 1 : RAW264.7 cell extracts, treated with UV (15mins)Lane 2 : RAW264.7 cell extracts, treated with UV (15mins) with immunizing peptide at 10 µgLysates/proteins at 30 µg per lane.
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