Gene Symbol | ZFHX3 |
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Entrez Gene | 463 |
Alt Symbol | ATBF1, ATBT, ZNF927 |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger homeobox 3 |
Other Description | AT motif-binding factor 1|AT-binding transcription factor 1|ZFH-3|alpha-fetoprotein enhancer binding protein|alpha-fetoprotein enhancer-binding protein|zinc finger homeobox protein 3|zinc finger homeodomain protein 3 |
Swissprots | O15101 Q13719 D3DWS8 Q15911 |
Accessions | AAC31674 AAC79153 AAR26475 EAW59168 EAW59169 EAW59170 Q15911 BC029653 AAH29653 BC043190 D10250 BAA01095 L32832 AAC14462 L32833 AAC37582 XM_005255957 XP_005256014 NM_001164766 NP_001158238 NM_006885 NP_008816 |
Function | Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down- regulates the MUC5AC promoter in gastric cancer. {ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level). {ECO:0000269|PubMed:17330845}. |
Top Pathways | Signaling pathways regulating pluripotency of stem cells |
ATBF1 CRISPR/Cas9 KO Plasmid (h) - sc-408112 from Santa Cruz Biotechnology
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ATBF1 HDR Plasmid (h) - sc-408112-HDR from Santa Cruz Biotechnology
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ATBF1 Double Nickase Plasmid (h) - sc-408112-NIC from Santa Cruz Biotechnology
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ATBF1 Double Nickase Plasmid (h2) - sc-408112-NIC-2 from Santa Cruz Biotechnology
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ATBF1 CRISPR Activation Plasmid (h) - sc-408112-ACT from Santa Cruz Biotechnology
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ATBF1 CRISPR Activation Plasmid (h2) - sc-408112-ACT-2 from Santa Cruz Biotechnology
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ATBF1 Lentiviral Activation Particles (h) - sc-408112-LAC from Santa Cruz Biotechnology
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ATBF1 Lentiviral Activation Particles (h2) - sc-408112-LAC-2 from Santa Cruz Biotechnology
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ATBF1 siRNA (h) - sc-37694 from Santa Cruz Biotechnology
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ATBF1 shRNA Plasmid (h) - sc-37694-SH from Santa Cruz Biotechnology
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ATBF1 shRNA (h) Lentiviral Particles - sc-37694-V from Santa Cruz Biotechnology
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ATBF1/ZFHX3 RNAi - H00000463-R01 from Novus Biologicals
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MISSION® esiRNA - EHU023021 from Sigma-Aldrich
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MISSION® esiRNA - EHU005711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23170 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23170 from Sigma-Aldrich
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ZFHX3 siRNA (Human) - CRH0323 from Cohesion Biosciences
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ZFHX3 - MBS8221780 from MyBioSource
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shRNA set against Human ZFHX3 (NM_006885.3) - SHH450256 from Creative biogene
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shRNA set against Human ATBF1(NM_006885.3) - SHL145880 from Creative biogene
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Human ZFHX3 siRNA - orb260825 from Biorbyt
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ZFHX3 shRNA Plasmid (Human) - CHH0323 from Cohesion Biosciences
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ZFHX3 miRNA 3'UTR clone - MiUTR1H-00654 from Creative biogene
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