LCK

Gene Symbol	LCK
Entrez Gene	3932
Alt Symbol	IMD22, LSK, YT16, p56lck, pp58lck
Species	Human
Gene Type	protein-coding
Description	LCK proto-oncogene, Src family tyrosine kinase
Other Description	T-lymphocyte specific protein tyrosine kinase p56lck|leukocyte C-terminal Src kinase|lymphocyte cell-specific protein-tyrosine kinase|lymphocyte-specific protein tyrosine kinase|p56(LSTRA) protein-tyrosine kinase|proto-oncogene tyrosine-protein kinase LCK|t cell-specific protein-tyrosine kinase|tyrosine-protein kinase Lck
Swissprots	P07100 Q12850 Q7RTZ3 Q9NYT8 Q13152 Q5TDH9 Q5TDH8 P06239 D3DPP8 Q96DW4
Accessions	AAA59501 AAA59503 CAA32211 CAD55807 EAX07542 EAX07543 EAX07544 EAX07545 EAX07546 P06239 AA747421 AF228313 AAF34794 AJ865079 CAI23831 AK098027 BAG53565 AK303073 BAG64189 BC013200 AAH13200 DA007906 DB122062 DB129997 DQ891675 ABM82601 DQ894861 ABM85787 HY261581 M36881 AAA59502 U07236 AAA18225 X04476 CAA28165 X05027 CAA28691 X06369 CAA29667 X13529 CAA31884 XM_011541453 XP_011539755 XM_011541454 XP_011539756 XM_011541455 XP_011539757 NM_001042771 NP_001036236 NM_005356 NP_005347
Function	Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited,
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12218089}. Cell membrane {ECO:0000269|PubMed:12218089}; Lipid-anchor {ECO:0000269|PubMed:12218089}; Cytoplasmic side {ECO:0000269|PubMed:12218089}. Note=Present in lipid rafts in an inactive form.
Tissue Specificity	Expressed specifically in lymphoid cells.
Top Pathways	Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Primary immunodeficiency, Osteoclast differentiation, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phospho-Lck (Tyr505) Antibody - 2751 from Cell Signaling Technology Prices $109.00, $287.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Lck (D88) XP ® Rabbit mAb - 2984 from Cell Signaling Technology Prices $109.00, $277.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D88

Lck (L22B1) Mouse mAb - 2657 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Mouse Clonality Monoclonal Clone L22B1

Lck (73A5) Rabbit mAb - 2787 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone 73A5

Lck (V49) Antibody - 2714 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Lck Antibody - 2752 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Lck (2102) - sc-13 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Lck (3A5) - sc-433 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Lck (B-10) - sc-166627 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Lck (D-8) - sc-166628 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Lck (L-20) - sc-32014 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Lck (H-95) - sc-28882 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Lck (SPM413) - sc-65579 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Lck (28) - sc-135971 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

Lck (0.T.84) - sc-71498 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

p-Lck (Tyr 394) - sc-101728 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

p-Lck (pY505.4) - sc-136184 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

Anti-Lck (phospho S158) antibody - ab4898 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-Lck (phospho Y192) antibody - ab138524 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Lck (phospho Y192) antibody - ab4900 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-Lck (phospho Y393) antibody - ab195787 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Lck (phospho Y393) antibody - ab138442 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Lck (phospho Y394) antibody [MM0795-71W27] - ab201567 from Abcam Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone MM0795-71W27

Anti-Lck (phospho Y505) antibody - ab195868 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Lck (phospho Y505) antibody - ab4901 from Abcam Prices $376.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

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